Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms

Hein Putter, Jeanine J. Houwing-Duistermaat, Nico J.D. Nagelkerke

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The aim of the present analysis is to combine evidence for association from the two most commonly used designs in genetic association analysis, the case-control design and the transmission disequilibrium test (TDT) design. The cases here are affected offspring from nuclear families and are used in both the case-control and TDT designs. As a result, inference from these designs is not independent. We applied a simple logistic regression method for combining evidence for association from case-control and TDT designs to single-nucleotide polymorphism data purchased on a region on chromosome 3, replicate 1 of the Aipotu population. Combining the evidence from the case-control and TDT designs yielded a 5-10% reduction in the standard errors of the relative risk estimates. The authors did not know the results before the analyses were conducted.

Original languageEnglish
Article numberS106
JournalBMC Genetics
Volume6
Issue numberSUPPL.1
DOIs
Publication statusPublished - Dec 30 2005
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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