TY - JOUR
T1 - Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms
AU - Putter, Hein
AU - Houwing-Duistermaat, Jeanine J.
AU - Nagelkerke, Nico J.D.
PY - 2005/12/30
Y1 - 2005/12/30
N2 - The aim of the present analysis is to combine evidence for association from the two most commonly used designs in genetic association analysis, the case-control design and the transmission disequilibrium test (TDT) design. The cases here are affected offspring from nuclear families and are used in both the case-control and TDT designs. As a result, inference from these designs is not independent. We applied a simple logistic regression method for combining evidence for association from case-control and TDT designs to single-nucleotide polymorphism data purchased on a region on chromosome 3, replicate 1 of the Aipotu population. Combining the evidence from the case-control and TDT designs yielded a 5-10% reduction in the standard errors of the relative risk estimates. The authors did not know the results before the analyses were conducted.
AB - The aim of the present analysis is to combine evidence for association from the two most commonly used designs in genetic association analysis, the case-control design and the transmission disequilibrium test (TDT) design. The cases here are affected offspring from nuclear families and are used in both the case-control and TDT designs. As a result, inference from these designs is not independent. We applied a simple logistic regression method for combining evidence for association from case-control and TDT designs to single-nucleotide polymorphism data purchased on a region on chromosome 3, replicate 1 of the Aipotu population. Combining the evidence from the case-control and TDT designs yielded a 5-10% reduction in the standard errors of the relative risk estimates. The authors did not know the results before the analyses were conducted.
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U2 - 10.1186/1471-2156-6-S1-S106
DO - 10.1186/1471-2156-6-S1-S106
M3 - Article
C2 - 16451562
AN - SCOPUS:30344488911
SN - 1471-2156
VL - 6
JO - BMC Genetics
JF - BMC Genetics
IS - SUPPL.1
M1 - S106
ER -