TY - JOUR
T1 - Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY
AU - Preston, Elaine
AU - Jönsson, Ann Cathrine
AU - McManus, Clare D.
AU - Conlon, J. Micheal
AU - Courtice, Gillian P.
N1 - Funding Information:
This study was supported by the Australian Research Council. We are grateful to New South Wales State Fisheries Department for collection of Port Jackson sharks, and to the Sydney Aquarium, Darling Harbour for maintenance of the sharks prior to experimentation. We would like to thank the director and staff of the Heron Island Research Station for allowing us to use their facilities, and Dr. M. Bennett, Dr. S. Bennett, Dr. L.C. Llewellyn and John and Lisa Chopin for their assistance in capture of the animals and in the laboratory at Heron Island. We would also like to thank Parvin Korchki for expert technical assistance with the immunohistochemistry.
PY - 1998/11/30
Y1 - 1998/11/30
N2 - The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.
AB - The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.
KW - Blood pressure
KW - Immunohistochemistry
KW - Isolated vessels
KW - NPY
KW - PYY
KW - Vasoconstriction
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U2 - 10.1016/S0167-0115(98)00116-5
DO - 10.1016/S0167-0115(98)00116-5
M3 - Article
C2 - 9879747
AN - SCOPUS:0032583198
SN - 0167-0115
VL - 78
SP - 57
EP - 67
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 1-3
ER -