Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

P. E.T. Isaacs; S. Ladas; I. C. Forgacs; R. H. Dowling; S. V. Ellam; T. E. Adrian; S. R. Bloom

doi:10.1007/BF01296030

Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

P. E.T. Isaacs, S. Ladas, I. C. Forgacs, R. H. Dowling, S. V. Ellam, T. E. Adrian, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Digestive Diseases and Sciences
Volume	32
Issue number	5
DOIs	https://doi.org/10.1007/BF01296030
Publication status	Published - May 1987
Externally published	Yes

Keywords

cholecystokinin
gallbladder motility
triglycerides

ASJC Scopus subject areas

Physiology
Gastroenterology

Access to Document

10.1007/BF01296030

Cite this

@article{c579ca6dad3d49a6b157a4f2965d7d89,

title = "Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides",

abstract = "In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.",

keywords = "cholecystokinin, gallbladder motility, triglycerides",

author = "Isaacs, {P. E.T.} and S. Ladas and Forgacs, {I. C.} and Dowling, {R. H.} and Ellam, {S. V.} and Adrian, {T. E.} and Bloom, {S. R.}",

year = "1987",

month = may,

doi = "10.1007/BF01296030",

language = "English",

volume = "32",

pages = "481--486",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Plenum Publishers",

number = "5",

}

TY - JOUR

T1 - Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

AU - Isaacs, P. E.T.

AU - Ladas, S.

AU - Forgacs, I. C.

AU - Dowling, R. H.

AU - Ellam, S. V.

AU - Adrian, T. E.

AU - Bloom, S. R.

PY - 1987/5

Y1 - 1987/5

N2 - In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

AB - In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

KW - cholecystokinin

KW - gallbladder motility

KW - triglycerides

UR - http://www.scopus.com/inward/record.url?scp=0023202030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023202030&partnerID=8YFLogxK

U2 - 10.1007/BF01296030

DO - 10.1007/BF01296030

M3 - Article

C2 - 3568934

AN - SCOPUS:0023202030

SN - 0163-2116

VL - 32

SP - 481

EP - 486

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 5

ER -

Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this