Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

Ahmed H. El-Sappah, Kuan Yan, Qiulan Huang, Md Monirul Islam, Quanzi Li, Yu Wang, Muhammad Sarwar Khan, Xianming Zhao, Reyazul Rouf Mir, Jia Li, Khaled A. El-Tarabily, Manzar Abbas

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5′ untranslated region (5′UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production.

Original languageEnglish
Article number705249
JournalFrontiers in Plant Science
Publication statusPublished - Sept 7 2021


  • CRISPR/Cas9
  • RNAi
  • genomics imprinting
  • paramutation
  • post-transcriptional gene silencing
  • transcriptional gene silencing

ASJC Scopus subject areas

  • Plant Science


Dive into the research topics of 'Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development'. Together they form a unique fingerprint.

Cite this