Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

Ahmed H. El-Sappah; Kuan Yan; Qiulan Huang; Md Monirul Islam; Quanzi Li; Yu Wang; Muhammad Sarwar Khan; Xianming Zhao; Reyazul Rouf Mir; Jia Li; Khaled A. El-Tarabily; Manzar Abbas

doi:10.3389/fpls.2021.705249

Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

Ahmed H. El-Sappah
, Kuan Yan
, Qiulan Huang
, Md Monirul Islam
, Quanzi Li
, Yu Wang
, Muhammad Sarwar Khan
, Xianming Zhao
, Reyazul Rouf Mir
, Jia Li
, Khaled A. El-Tarabily
, Manzar Abbas

Department of Biology

Research output: Contribution to journal › Review article › peer-review

82 Citations (Scopus)

Abstract

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5′ untranslated region (5′UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production.

Original language	English
Article number	705249
Journal	Frontiers in Plant Science
Volume	12
DOIs	https://doi.org/10.3389/fpls.2021.705249
Publication status	Published - Sept 7 2021

Keywords

CRISPR/Cas9
RNAi
genomics imprinting
paramutation
post-transcriptional gene silencing
transcriptional gene silencing

ASJC Scopus subject areas

Plant Science

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10.3389/fpls.2021.705249

Cite this

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title = "Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development",

abstract = "Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5′ untranslated region (5′UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production.",

keywords = "CRISPR/Cas9, RNAi, genomics imprinting, paramutation, post-transcriptional gene silencing, transcriptional gene silencing",

author = "El-Sappah, \{Ahmed H.\} and Kuan Yan and Qiulan Huang and Islam, \{Md Monirul\} and Quanzi Li and Yu Wang and Khan, \{Muhammad Sarwar\} and Xianming Zhao and Mir, \{Reyazul Rouf\} and Jia Li and El-Tarabily, \{Khaled A.\} and Manzar Abbas",

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month = sep,

day = "7",

doi = "10.3389/fpls.2021.705249",

language = "English",

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T1 - Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

AU - El-Sappah, Ahmed H.

AU - Yan, Kuan

AU - Huang, Qiulan

AU - Islam, Md Monirul

AU - Li, Quanzi

AU - Wang, Yu

AU - Khan, Muhammad Sarwar

AU - Zhao, Xianming

AU - Mir, Reyazul Rouf

AU - Li, Jia

AU - El-Tarabily, Khaled A.

AU - Abbas, Manzar

PY - 2021/9/7

Y1 - 2021/9/7

N2 - Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5′ untranslated region (5′UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production.

AB - Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5′ untranslated region (5′UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production.

KW - CRISPR/Cas9

KW - RNAi

KW - genomics imprinting

KW - paramutation

KW - post-transcriptional gene silencing

KW - transcriptional gene silencing

UR - https://www.scopus.com/pages/publications/85115865255

UR - https://www.scopus.com/pages/publications/85115865255#tab=citedBy

U2 - 10.3389/fpls.2021.705249

DO - 10.3389/fpls.2021.705249

M3 - Review article

AN - SCOPUS:85115865255

SN - 1664-462X

VL - 12

JO - Frontiers in Plant Science

JF - Frontiers in Plant Science

M1 - 705249

ER -

Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

Abstract

Keywords

ASJC Scopus subject areas

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