Computational modeling approaches in gonadotropin signaling

Mohammed Akli Ayoub, Romain Yvinec, Pascale Crépieux, Anne Poupon

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Follicle-stimulating hormone and LH play essential roles in animal reproduction. They exert their function through binding to their cognate receptors, which belong to the large family of G protein-coupled receptors. This recognition at the plasma membrane triggers a plethora of cellular events, whose processing and integration ultimately lead to an adapted biological response. Understanding the nature and the kinetics of these events is essential for innovative approaches in drug discovery. The study and manipulation of such complex systems requires the use of computational modeling approaches combined with robust in vitro functional assays for calibration and validation. Modeling brings a detailed understanding of the system and can also be used to understand why existing drugs do not work as well as expected, and how to design more efficient ones.

Original languageEnglish
Pages (from-to)22-31
Number of pages10
Issue number1
Publication statusPublished - Jul 1 2016
Externally publishedYes


  • Gonadotropins
  • Mathematical modeling
  • Systems biology

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine


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