TY - GEN
T1 - Conotoxin protein classification using pairwise comparison and amino acid composition
AU - Zaki, Nazar
AU - Sibai, Fadi
AU - Campbell, Piers
PY - 2011
Y1 - 2011
N2 - Conotoxin classification could assist in the study of the structure function relationship of ion-channels and receptors as well as identifying potential therapeutics in the treatment of a wide variety of diseases such as schizophrenia, chronic pain, cardiovascular and bladder dysfunction. In this study, we introduce a novel method (Toxin-AAM) for conotoxin su-perfamily classification. Toxin-AAM incorporates evolutionary information using a powerful means of pairwise sequence comparison and amino acid composition knowledge. The combination of the sequential model and the discrete model has made the Toxin-AAM method exceptional in classifying conotoxin superfamily, when compared to other state-of-the-art techniques.
AB - Conotoxin classification could assist in the study of the structure function relationship of ion-channels and receptors as well as identifying potential therapeutics in the treatment of a wide variety of diseases such as schizophrenia, chronic pain, cardiovascular and bladder dysfunction. In this study, we introduce a novel method (Toxin-AAM) for conotoxin su-perfamily classification. Toxin-AAM incorporates evolutionary information using a powerful means of pairwise sequence comparison and amino acid composition knowledge. The combination of the sequential model and the discrete model has made the Toxin-AAM method exceptional in classifying conotoxin superfamily, when compared to other state-of-the-art techniques.
KW - Amino acid composition
KW - Conotoxin classification
KW - Pairwise alignment
UR - http://www.scopus.com/inward/record.url?scp=84860404007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860404007&partnerID=8YFLogxK
U2 - 10.1145/2001576.2001621
DO - 10.1145/2001576.2001621
M3 - Conference contribution
AN - SCOPUS:84860404007
SN - 9781450305570
T3 - Genetic and Evolutionary Computation Conference, GECCO'11
SP - 323
EP - 329
BT - Genetic and Evolutionary Computation Conference, GECCO'11
T2 - 13th Annual Genetic and Evolutionary Computation Conference, GECCO'11
Y2 - 12 July 2011 through 16 July 2011
ER -