TY - JOUR
T1 - Consanguinity decreases risk of breast cancer - Cervical cancer unaffected
AU - Denic, S.
AU - Bener, A.
N1 - Funding Information:
The authors thank Dr Hussain Saadi for critical review of the manuscript and acknowledge contribution of the reviewers in preparation of the manuscript. This project was funded by the grant (NP/99/5) to one of us (AB) from the Faculty of Medicine and Health Sciences, UAE University, Al Ain, Abu Dhabi, UAE.
PY - 2001/11/30
Y1 - 2001/11/30
N2 - Marriages between third-degree and more distant relatives are common in many parts of the world. Offspring of consanguineous parents have increased morbidity and mortality related to recessive gene disorders. In a population with a high frequency of consanguinity, we examined the frequency of breast cancer (related in part to tumour genes) and cervical cancers (related to virus infection) among offspring of consanguineous and non-consanguineous parents. Study was done prospectively in the United Arab Emirates. Selected were married female citizens, ages 40-65, who attended 12 primary health care clinics for whatever reason. In a face-to-face interview, subjects were asked: (a) about consanguineous marriages in family; (b) if they have or have had breast or cervical cancer; (c) about family history of cancer, cancer screening and other parameters. Tumour diagnosis was confirmed by review of medical records. Of 1750 women invited into study, 1445 (79%) could be used in analysis. Among 579 (40%) women of consanguineous and 866 (60%) of non-consanguineous parents there were 24 and 54 with breast cancer, respectively (RR = 0.66, CI 0.42 - 1.06). In the 40 to 50 age group, breast cancer reported 13 of 446 women of consanguineous and 37 of 633 of non-consanguineous parents (RR = 0.50, CI 0.27-0.93). Cervical cancer had 15 women in consanguineous and 32 in non-consanguineous group (RR = 0.70, CI 0.38 - 1.28). Number of families with history of breast cancer in consanguineous and non-consanguineous group was 21 and 23, respectively (P = 0.29). The cancer screening rates and other variable values had fairly balanced distribution between the 2 groups. Having consanguineous parents decreases the risk of breast cancer especially in younger women, risk of cervical cancer being unaffected.
AB - Marriages between third-degree and more distant relatives are common in many parts of the world. Offspring of consanguineous parents have increased morbidity and mortality related to recessive gene disorders. In a population with a high frequency of consanguinity, we examined the frequency of breast cancer (related in part to tumour genes) and cervical cancers (related to virus infection) among offspring of consanguineous and non-consanguineous parents. Study was done prospectively in the United Arab Emirates. Selected were married female citizens, ages 40-65, who attended 12 primary health care clinics for whatever reason. In a face-to-face interview, subjects were asked: (a) about consanguineous marriages in family; (b) if they have or have had breast or cervical cancer; (c) about family history of cancer, cancer screening and other parameters. Tumour diagnosis was confirmed by review of medical records. Of 1750 women invited into study, 1445 (79%) could be used in analysis. Among 579 (40%) women of consanguineous and 866 (60%) of non-consanguineous parents there were 24 and 54 with breast cancer, respectively (RR = 0.66, CI 0.42 - 1.06). In the 40 to 50 age group, breast cancer reported 13 of 446 women of consanguineous and 37 of 633 of non-consanguineous parents (RR = 0.50, CI 0.27-0.93). Cervical cancer had 15 women in consanguineous and 32 in non-consanguineous group (RR = 0.70, CI 0.38 - 1.28). Number of families with history of breast cancer in consanguineous and non-consanguineous group was 21 and 23, respectively (P = 0.29). The cancer screening rates and other variable values had fairly balanced distribution between the 2 groups. Having consanguineous parents decreases the risk of breast cancer especially in younger women, risk of cervical cancer being unaffected.
KW - BRCA1
KW - BRCA2
KW - Breast cancer
KW - Cervical cancer
KW - Consanguinity
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UR - http://www.scopus.com/inward/citedby.url?scp=0035977177&partnerID=8YFLogxK
U2 - 10.1054/bjoc.2001.2131
DO - 10.1054/bjoc.2001.2131
M3 - Article
C2 - 11742487
AN - SCOPUS:0035977177
SN - 0007-0920
VL - 85
SP - 1675
EP - 1679
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -