Abstract
Sesame seed and oil consumption previously increased human plasma γ-tocopherol (γ-T) concentrations. This was attributed to the sesame lignans sesamin and sesamolin. Here, we studied the inhibition of vitamin E metabolism by a single dose of sesame oil lignans coingested with deuterated α- and γ-tocopherols in human volunteers. The urinary excretion of γ-T metabolites was significantly lower in sesame oil treated than in control subjects. Concentrations of tocopherols in blood were not affected by the treatment. In conclusion, a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered γ-T in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 365-367 |
| Number of pages | 3 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1031 |
| DOIs | |
| Publication status | Published - 2004 |
| Externally published | Yes |
Keywords
- CEHC
- Carboxyethyl hydroxychromans
- Lignans
- Sesame
- Sesamin
- Sesamolin
- Tocopherol
- Vitamin E
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry,Genetics and Molecular Biology
- History and Philosophy of Science
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