Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Mireia Toledano-Pinedo; Daniel Diez-Iriepa; Alicia Porro-Pérez; Linda Schäker-Hübner; Maria Hanl; Abdelouahid Samadi; Pedro Almendros; Isabel Iriepa; M. Mercedes Rodríguez-Fernández; Christian Griñán-Ferré; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroż-Płonka; Jadwiga Handzlik; Justyna Godyń; Damijan Knez; Stanislav Gobec; Anna Więckowska; Finn K. Hansen; José Marco-Contelles

doi:10.1055/s-0043-1775419

Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Mireia Toledano-Pinedo, Daniel Diez-Iriepa, Alicia Porro-Pérez, Linda Schäker-Hübner, Maria Hanl, Abdelouahid Samadi, Pedro Almendros, Isabel Iriepa, M. Mercedes Rodríguez-Fernández, Christian Griñán-Ferré, Agata Siwek, Małgorzata Wolak, Grzegorz Satała, Andrzej J. Bojarski, Agata Doroż-Płonka, Jadwiga Handzlik, Justyna Godyń, Damijan Knez, Stanislav Gobec, Anna WięckowskaFinn K. Hansen, José Marco-Contelles

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.

Original language	English
Journal	Synlett
DOIs	https://doi.org/10.1055/s-0043-1775419
Publication status	Accepted/In press - 2024

Keywords

contilistat
docking analysis
indoles
medicinal chemistry
multitarget drugs

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0043-1775419

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Toledano-Pinedo, M., Diez-Iriepa, D., Porro-Pérez, A., Schäker-Hübner, L., Hanl, M., Samadi, A., Almendros, P., Iriepa, I., Rodríguez-Fernández, M. M., Griñán-Ferré, C., Siwek, A., Wolak, M., Satała, G., Bojarski, A. J., Doroż-Płonka, A., Handzlik, J., Godyń, J., Knez, D., Gobec, S., ... Marco-Contelles, J. (Accepted/In press). Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative. Synlett. https://doi.org/10.1055/s-0043-1775419

Toledano-Pinedo, M, Diez-Iriepa, D, Porro-Pérez, A, Schäker-Hübner, L, Hanl, M, Samadi, A, Almendros, P, Iriepa, I, Rodríguez-Fernández, MM, Griñán-Ferré, C, Siwek, A, Wolak, M, Satała, G, Bojarski, AJ, Doroż-Płonka, A, Handzlik, J, Godyń, J, Knez, D, Gobec, S, Więckowska, A, Hansen, FK & Marco-Contelles, J 2024, 'Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative', Synlett. https://doi.org/10.1055/s-0043-1775419

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abstract = "We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.",

keywords = "contilistat, docking analysis, indoles, medicinal chemistry, multitarget drugs",

author = "Mireia Toledano-Pinedo and Daniel Diez-Iriepa and Alicia Porro-P{\'e}rez and Linda Sch{\"a}ker-H{\"u}bner and Maria Hanl and Abdelouahid Samadi and Pedro Almendros and Isabel Iriepa and Rodr{\'i}guez-Fern{\'a}ndez, \{M. Mercedes\} and Christian Gri{\~n}{\'a}n-Ferr{\'e} and Agata Siwek and Ma{\l}gorzata Wolak and Grzegorz Sata{\l}a and Bojarski, \{Andrzej J.\} and Agata Doro{\.z}-P{\l}onka and Jadwiga Handzlik and Justyna Gody{\'n} and Damijan Knez and Stanislav Gobec and Anna Wi{\c e}ckowska and Hansen, \{Finn K.\} and Jos{\'e} Marco-Contelles",

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doi = "10.1055/s-0043-1775419",

language = "English",

journal = "Synlett",

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T1 - Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

AU - Toledano-Pinedo, Mireia

AU - Diez-Iriepa, Daniel

AU - Porro-Pérez, Alicia

AU - Schäker-Hübner, Linda

AU - Hanl, Maria

AU - Samadi, Abdelouahid

AU - Almendros, Pedro

AU - Iriepa, Isabel

AU - Rodríguez-Fernández, M. Mercedes

AU - Griñán-Ferré, Christian

AU - Siwek, Agata

AU - Wolak, Małgorzata

AU - Satała, Grzegorz

AU - Bojarski, Andrzej J.

AU - Doroż-Płonka, Agata

AU - Handzlik, Jadwiga

AU - Godyń, Justyna

AU - Knez, Damijan

AU - Gobec, Stanislav

AU - Więckowska, Anna

AU - Hansen, Finn K.

AU - Marco-Contelles, José

PY - 2024

Y1 - 2024

N2 - We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.

AB - We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.

KW - contilistat

KW - docking analysis

KW - indoles

KW - medicinal chemistry

KW - multitarget drugs

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DO - 10.1055/s-0043-1775419

M3 - Article

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SN - 0936-5214

JO - Synlett

JF - Synlett

ER -

Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Abstract

Keywords

ASJC Scopus subject areas

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