Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Mireia Toledano-Pinedo; Daniel Diez-Iriepa; Alicia Porro-Pérez; Linda Schäker-Hübner; Maria Hanl; Abdelouahid Samadi; Pedro Almendros; Isabel Iriepa; M. Mercedes Rodríguez-Fernández; Christian Griñán-Ferré; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroż-Płonka; Jadwiga Handzlik; Justyna Godyń; Damijan Knez; Stanislav Gobec; Anna Więckowska; Finn K. Hansen; José Marco-Contelles

doi:10.1055/s-0043-1775419

Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Mireia Toledano-Pinedo
, Daniel Diez-Iriepa
, Alicia Porro-Pérez
, Linda Schäker-Hübner
, Maria Hanl
, Abdelouahid Samadi
, Pedro Almendros
, Isabel Iriepa
, M. Mercedes Rodríguez-Fernández
, Christian Griñán-Ferré
, Agata Siwek
, Małgorzata Wolak
, Grzegorz Satała
, Andrzej J. Bojarski
, Agata Doroż-Płonka
, Jadwiga Handzlik
, Justyna Godyń
, Damijan Knez
, Stanislav Gobec
, Anna Więckowska

Finn K. Hansen, José Marco-Contelles

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.

Original language	English
Pages (from-to)	2655-2660
Number of pages	6
Journal	Synlett
Volume	36
Issue number	16
DOIs	https://doi.org/10.1055/s-0043-1775419
Publication status	Published - Oct 1 2025

Keywords

contilistat
docking analysis
indoles
medicinal chemistry
multitarget drugs

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0043-1775419

Cite this

Toledano-Pinedo, M., Diez-Iriepa, D., Porro-Pérez, A., Schäker-Hübner, L., Hanl, M., Samadi, A., Almendros, P., Iriepa, I., Rodríguez-Fernández, M. M., Griñán-Ferré, C., Siwek, A., Wolak, M., Satała, G., Bojarski, A. J., Doroż-Płonka, A., Handzlik, J., Godyń, J., Knez, D., Gobec, S., ... Marco-Contelles, J. (2025). Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative. Synlett, 36(16), 2655-2660. https://doi.org/10.1055/s-0043-1775419

Toledano-Pinedo, M, Diez-Iriepa, D, Porro-Pérez, A, Schäker-Hübner, L, Hanl, M, Samadi, A, Almendros, P, Iriepa, I, Rodríguez-Fernández, MM, Griñán-Ferré, C, Siwek, A, Wolak, M, Satała, G, Bojarski, AJ, Doroż-Płonka, A, Handzlik, J, Godyń, J, Knez, D, Gobec, S, Więckowska, A, Hansen, FK & Marco-Contelles, J 2025, 'Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative', Synlett, vol. 36, no. 16, pp. 2655-2660. https://doi.org/10.1055/s-0043-1775419

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AU - Toledano-Pinedo, Mireia

AU - Diez-Iriepa, Daniel

AU - Porro-Pérez, Alicia

AU - Schäker-Hübner, Linda

AU - Hanl, Maria

AU - Samadi, Abdelouahid

AU - Almendros, Pedro

AU - Iriepa, Isabel

AU - Rodríguez-Fernández, M. Mercedes

AU - Griñán-Ferré, Christian

AU - Siwek, Agata

AU - Wolak, Małgorzata

AU - Satała, Grzegorz

AU - Bojarski, Andrzej J.

AU - Doroż-Płonka, Agata

AU - Handzlik, Jadwiga

AU - Godyń, Justyna

AU - Knez, Damijan

AU - Gobec, Stanislav

AU - Więckowska, Anna

AU - Hansen, Finn K.

AU - Marco-Contelles, José

PY - 2025/10/1

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AB - We describe the design, synthesis, and in vitro biological evaluation of contilistat, a novel polyfunctionalized indole derivative designed as a hybrid of contilisant and vorinostat containing key pharmacophoric groups of both parent ligands.

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KW - docking analysis

KW - indoles

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KW - multitarget drugs

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IS - 16

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Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Abstract

Keywords

ASJC Scopus subject areas

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