Continuous Dynamic Bayesian Network for gene regulatory network modelling

Norhaini Baba, Mohd Saberi Mohamad, Abdul Hakim Mohamed Salleh, Mohd Hanafi Ahmad Hijazi, Lian En Chai, Muhammad Mahfuz Zainuddin, Safaai Deris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In order to understand the underlying function of organisms, it is necessary to study the behaviour of genes in a gene regulatory network context. Several computational approaches are available for modelling gene regulatory networks with different datasets. Hence, this research is conducted to model the gene regulatory gene network using the proposed computational approach which is the Dynamic Bayesian Network. Dynamic Bayesian Network (DBN) is extensively used to construct GRNs based on its ability to handle microarray data and modelling feedback loops (cyclic regulation). The DBN approach is then extended to the continuous Dynamic Bayesian Network (cDBN) to construct a gene regulatory network with continuous data without discretization. The performance of the constructed gene networks of Saccharomyces cerevisiae were evaluated and compared with the previous works. At the end of this research, the gene networks constructed for Saccharomy cescerevisiae discovered more potential interactions between genes. Therefore, it can be concluded that the performance of the gene regulatory networks constructed using continuous dynamic Bayesian networks in this research is proven to be better because it can reveal more gene relationships as well as allowing feedback loops or cyclic regulation.

Original languageEnglish
Title of host publication2014 International Conference on Computational Science and Technology, ICCST 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479932412
DOIs
Publication statusPublished - Feb 18 2014
Externally publishedYes
Event2014 International Conference on Computational Science and Technology, ICCST 2014 - Kota Kinabalu, Sabah, Malaysia
Duration: Aug 27 2014Aug 28 2014

Publication series

Name2014 International Conference on Computational Science and Technology, ICCST 2014

Conference

Conference2014 International Conference on Computational Science and Technology, ICCST 2014
Country/TerritoryMalaysia
CityKota Kinabalu, Sabah
Period8/27/148/28/14

Keywords

  • dynamic bayesian network
  • gene expression data
  • gene regulatory networks

ASJC Scopus subject areas

  • General Computer Science

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