Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy

Kichinosuke Kamata; Yoh Ichi Tominaga; Akiyoshi Tori-I; Thies Thiemann; Kazufumi Takahashi; Shuntaro Mataka

doi:10.3987/com-02-9523

Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy

Kichinosuke Kamata, Yoh Ichi Tominaga, Akiyoshi Tori-I, Thies Thiemann, Kazufumi Takahashi, Shuntaro Mataka

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.

Original language	English
Pages (from-to)	1683-1688
Number of pages	6
Journal	Heterocycles
Volume	57
Issue number	9
DOIs	https://doi.org/10.3987/com-02-9523
Publication status	Published - Sept 1 2002
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.",

author = "Kichinosuke Kamata and Tominaga, {Yoh Ichi} and Akiyoshi Tori-I and Thies Thiemann and Kazufumi Takahashi and Shuntaro Mataka",

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T1 - Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy

AU - Kamata, Kichinosuke

AU - Tominaga, Yoh Ichi

AU - Tori-I, Akiyoshi

AU - Thiemann, Thies

AU - Takahashi, Kazufumi

AU - Mataka, Shuntaro

PY - 2002/9/1

Y1 - 2002/9/1

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AB - 9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.

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Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy

Abstract

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