COVID-19 Detection via Silicon Nanowire Field-Effect Transistor: Setup and Modeling of Its Function

Asma Wasfi, Falah Awwad, Juri George Gelovani, Naser Qamhieh, Ahmad I. Ayesh

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Biomolecular detection methods have evolved from simple chemical processes to laboratory sensors capable of acquiring accurate measurements of various biological components. Recently, silicon nanowire field-effect transistors (SiNW-FETs) have been drawing enormous interest due to their potential in the biomolecular sensing field. SiNW-FETs exhibit capabilities such as providing real-time, label-free, highly selective, and sensitive detection. It is highly critical to diagnose infectious diseases accurately to reduce the illness and death spread rate. In this work, a novel SiNW-FET sensor is designed using a semiempirical approach, and the electronic transport properties are studied to detect the COVID-19 spike protein. Various electronic transport properties such as transmission spectrum, conductance, and electronic current are investigated by a semiempirical modeling that is combined with a nonequilibrium Green’s function. Moreover, the developed sensor selectivity is tested by studying the electronic transport properties for other viruses including influenza, rotavirus, and HIV. The results indicate that SiNW-FET can be utilized for accurate COVID-19 identification with high sensitivity and selectivity.

Original languageEnglish
Article number2638
Issue number15
Publication statusPublished - Aug 2022


  • COVID-19
  • FET biosensor
  • semiempirical modeling

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science


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