TY - JOUR
T1 - Critical appraisal of the recent data published on the link between insulin and cancer
AU - Ghosal, Samit
AU - Stephens, Jeff
AU - Van Deventer, Annalie
AU - Mital, Vikas
AU - Jayasinghe, Priyangika
AU - Khan, Moien
AU - Setch, Loui
AU - Pauly, Bruno
PY - 2011
Y1 - 2011
N2 - Recent publications indicate a possible association between newer analogue insulin Glargine and cancer. However all these data were observational in nature and subject to lot of methodological errors. It is practically impossible to derive at a cause and effect relationship based on these observational studies. There are several confounding factors like hyperinsulinemia, obesity and smoking, which independently can be associated with cancer risk. This review looks into the recently published observational studies from the methodological point of view and whether such a negative association can indeed be drawn as a conclusion. Several methodological defects were identified in the process of scrutiny and we concluded it is not possible to conclude that there is an association between Glargine use and cancer. However long-term prospective data is required to come to definite conclusion.
AB - Recent publications indicate a possible association between newer analogue insulin Glargine and cancer. However all these data were observational in nature and subject to lot of methodological errors. It is practically impossible to derive at a cause and effect relationship based on these observational studies. There are several confounding factors like hyperinsulinemia, obesity and smoking, which independently can be associated with cancer risk. This review looks into the recently published observational studies from the methodological point of view and whether such a negative association can indeed be drawn as a conclusion. Several methodological defects were identified in the process of scrutiny and we concluded it is not possible to conclude that there is an association between Glargine use and cancer. However long-term prospective data is required to come to definite conclusion.
KW - Cancer
KW - Glargine
KW - Hyperinsulinemia
KW - Insulin resistance
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U2 - 10.1016/j.dsx.2012.03.004
DO - 10.1016/j.dsx.2012.03.004
M3 - Article
C2 - 25572765
AN - SCOPUS:84864414939
SN - 1871-4021
VL - 5
SP - 211
EP - 213
JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
IS - 4
ER -