Crosstalk between cancer and the neuro-immune system

Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)


In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system plays a fundamental role in regulating immune responses to a range of disease states including cancer. Its dysfunction influences the progression of cancer. The role of the immune system in tumor progression is of relevance to the nervous system since they can bi-directionally communicate via neurotransmitters and neuropeptides, common receptors, and, cytokines. However, cross-talk between these cells is highly complex in nature, and numerous variations are possible according to the type of cancer involved. The neuro-immune interaction is essential in influencing cancer development and progression.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalJournal of Neuroimmunology
Publication statusPublished - Feb 15 2018
Externally publishedYes


  • Cancer-associated immune cells
  • Nervous system
  • Neuro-immune interaction
  • Neuropeptides
  • Neurotransmitters

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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