TY - JOUR
T1 - Crosstalk between cancer and the neuro-immune system
AU - Kuol, Nyanbol
AU - Stojanovska, Lily
AU - Apostolopoulos, Vasso
AU - Nurgali, Kulmira
N1 - Funding Information:
NK was supported by an Australian Postgraduate Research Award , LS and KN were supported by the College of Heath and Biomedicine Victoria University , Australia and VA was supported by the Centre for Chronic Disease, Victoria University , Australia.
Funding Information:
NK was supported by an Australian Postgraduate Research Award, LS and KN were supported by the College of Heath and Biomedicine Victoria University, Australia and VA was supported by the Centre for Chronic Disease, Victoria University, Australia.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/2/15
Y1 - 2018/2/15
N2 - In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system plays a fundamental role in regulating immune responses to a range of disease states including cancer. Its dysfunction influences the progression of cancer. The role of the immune system in tumor progression is of relevance to the nervous system since they can bi-directionally communicate via neurotransmitters and neuropeptides, common receptors, and, cytokines. However, cross-talk between these cells is highly complex in nature, and numerous variations are possible according to the type of cancer involved. The neuro-immune interaction is essential in influencing cancer development and progression.
AB - In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system plays a fundamental role in regulating immune responses to a range of disease states including cancer. Its dysfunction influences the progression of cancer. The role of the immune system in tumor progression is of relevance to the nervous system since they can bi-directionally communicate via neurotransmitters and neuropeptides, common receptors, and, cytokines. However, cross-talk between these cells is highly complex in nature, and numerous variations are possible according to the type of cancer involved. The neuro-immune interaction is essential in influencing cancer development and progression.
KW - Cancer-associated immune cells
KW - Nervous system
KW - Neuro-immune interaction
KW - Neuropeptides
KW - Neurotransmitters
UR - http://www.scopus.com/inward/record.url?scp=85038936205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038936205&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2017.12.016
DO - 10.1016/j.jneuroim.2017.12.016
M3 - Review article
C2 - 29306400
AN - SCOPUS:85038936205
SN - 0165-5728
VL - 315
SP - 15
EP - 23
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -