Current Understanding of Novel Coronavirus: Molecular Pathogenesis, Diagnosis, and Treatment Approaches

Niraj Kumar Jha, Madhan Jeyaraman, Mahesh Rachamalla, Shreesh Ojha, Kamal Dua, Dinesh Kumar Chellappan, Sathish Muthu, Ankur Sharma, Saurabh Kumar Jha, Rashmi Jain, Naveen Jeyaraman, Prajwal GS, Rohit Satyam, Fahad Khan, Pratibha Pandey, Nitin Verma, Sandeep Kumar Singh, Shubhadeep Roychoudhury, Sunny Dholpuria, Janne RuokolainenKavindra Kumar Kesari

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


An outbreak of “Pneumonia of Unknown Etiology” occurred in Wuhan, China, in late December 2019. Later, the agent factor was identified and coined as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the disease was named coronavirus disease 2019 (COVID-19). In a shorter period, this newly emergent infection brought the world to a standstill. On 11 March 2020, the WHO declared COVID-19 as a pandemic. Researchers across the globe have joined their hands to investigate SARS-CoV-2 in terms of pathogenicity, transmissibility, and deduce therapeutics to subjugate this infection. The researchers and scholars practicing different arts of medicine are on an extensive quest to come up with safer ways to curb the pathological implications of this viral infection. A huge number of clinical trials are underway from the branch of allopathy and naturopathy. Besides, a paradigm shift on cellular therapy and nano-medicine protocols has to be optimized for better clinical and functional outcomes of COVID-19-affected individuals. This article unveils a comprehensive review of the pathogenesis mode of spread, and various treatment modalities to combat COVID-19 disease.

Original languageEnglish
Issue number1
Publication statusPublished - Mar 2021


  • COVID-19
  • SARS-CoV-2
  • management
  • natural products
  • pathogenesis
  • therapeutics
  • treatment
  • vaccines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Immunology
  • Medicine (miscellaneous)


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