Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

Martin Vordermeier; Gobena Ameni; Elizabeth J. Glass

doi:10.1007/s11250-011-9950-x

Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

Martin Vordermeier
, Gobena Ameni
, Elizabeth J. Glass

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Recently, we found that Holstein cattle (Bos taurus taurus) displayed higher skin test prevalence and disease severity compared to zebu (Bos taurus indicus) herd-mates kept under identical husbandry conditions in Ethiopia. To determine whether these susceptibility differences were patent at the level of the innate immune system, we infected monocytes from naïve Holstein or Sahiwal zebu cattle with either live virulent Mycobacterium tuberculosis or Mycobacterium bovis. The cytokine profile following infection was compared between the two breeds by measuring IL-1α, IL-6, IL-10, IL-12 and TNF-α as well as nitric oxide in culture supernatants. Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle.

Original language	English
Pages (from-to)	651-655
Number of pages	5
Journal	Tropical Animal Health and Production
Volume	44
Issue number	3
DOIs	https://doi.org/10.1007/s11250-011-9950-x
Publication status	Published - Mar 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bovine tuberculosis
Cattle
Cytokines
Holstein
Mycobacterium bovis
Mycobacterium tuberculosis
Zebu

ASJC Scopus subject areas

Food Animals
Animal Science and Zoology

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10.1007/s11250-011-9950-x

Cite this

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title = "Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection",

abstract = "Recently, we found that Holstein cattle (Bos taurus taurus) displayed higher skin test prevalence and disease severity compared to zebu (Bos taurus indicus) herd-mates kept under identical husbandry conditions in Ethiopia. To determine whether these susceptibility differences were patent at the level of the innate immune system, we infected monocytes from na{\"i}ve Holstein or Sahiwal zebu cattle with either live virulent Mycobacterium tuberculosis or Mycobacterium bovis. The cytokine profile following infection was compared between the two breeds by measuring IL-1α, IL-6, IL-10, IL-12 and TNF-α as well as nitric oxide in culture supernatants. Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle.",

keywords = "Bovine tuberculosis, Cattle, Cytokines, Holstein, Mycobacterium bovis, Mycobacterium tuberculosis, Zebu",

author = "Martin Vordermeier and Gobena Ameni and Glass, \{Elizabeth J.\}",

note = "Funding Information: Acknowledgements We would like to thank Dr C. Garcia-Pelayo (VLA Weybridge) for providing mycobacterial stocks for the infection experiments. The work was supported by the Wellcome Trust. We also like to thank Dr Jayne Hope (Institute for Animal Health, Compton, UK) for the supply of bovine cytokines. Dr. Glass received financial support from the Biotechnology and Biological Sciences Research Council (BBSRC) through Institute Strategic Grant funding as well as Grant number 215/S15354, and the Wellcome Trust {\textquoteleft}Animal Health in the Developing World Initiative{\textquoteright} grant. [Grant number 075820/A/04/Z].",

year = "2012",

month = mar,

doi = "10.1007/s11250-011-9950-x",

language = "English",

volume = "44",

pages = "651--655",

journal = "Tropical Animal Health and Production",

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T1 - Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

AU - Vordermeier, Martin

AU - Ameni, Gobena

AU - Glass, Elizabeth J.

N1 - Funding Information: Acknowledgements We would like to thank Dr C. Garcia-Pelayo (VLA Weybridge) for providing mycobacterial stocks for the infection experiments. The work was supported by the Wellcome Trust. We also like to thank Dr Jayne Hope (Institute for Animal Health, Compton, UK) for the supply of bovine cytokines. Dr. Glass received financial support from the Biotechnology and Biological Sciences Research Council (BBSRC) through Institute Strategic Grant funding as well as Grant number 215/S15354, and the Wellcome Trust ‘Animal Health in the Developing World Initiative’ grant. [Grant number 075820/A/04/Z].

PY - 2012/3

Y1 - 2012/3

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KW - Cattle

KW - Cytokines

KW - Holstein

KW - Mycobacterium bovis

KW - Mycobacterium tuberculosis

KW - Zebu

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Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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