CYTOTOXIC ACTIVITY AGAINST HUMAN LUNG CANCER CELL LINE (A549) OF DIMETHYL-TIN(IV) VALSARTAN COMPLEX

Alaa Mohammed; Muataz Ali; Wedad Al-Dahhan; Israa Salamn; Muna Bufaroosha; Dheaa Zageer; Emad Yousif

doi:10.5958/0974-4614.2022.00059.6

CYTOTOXIC ACTIVITY AGAINST HUMAN LUNG CANCER CELL LINE (A549) OF DIMETHYL-TIN(IV) VALSARTAN COMPLEX

Alaa Mohammed, Muataz Ali, Wedad Al-Dahhan, Israa Salamn, Muna Bufaroosha, Dheaa Zageer, Emad Yousif

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR,¹H-NMR and¹¹⁹Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me₂ SnL₂ complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.

Original language	English
Pages (from-to)	102-106
Number of pages	5
Journal	International Journal of Medical Toxicology and Legal Medicine
Volume	25
Issue number	3-4
DOIs	https://doi.org/10.5958/0974-4614.2022.00059.6
Publication status	Published - Jul 1 2022

Keywords

A549 cell line
biological activity
MTT assay
Tin complex
Valsartan

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5958/0974-4614.2022.00059.6

Cite this

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title = "CYTOTOXIC ACTIVITY AGAINST HUMAN LUNG CANCER CELL LINE (A549) OF DIMETHYL-TIN(IV) VALSARTAN COMPLEX",

abstract = "Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR,1H-NMR and119Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me2 SnL2 complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.",

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author = "Alaa Mohammed and Muataz Ali and Wedad Al-Dahhan and Israa Salamn and Muna Bufaroosha and Dheaa Zageer and Emad Yousif",

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AU - Mohammed, Alaa

AU - Ali, Muataz

AU - Al-Dahhan, Wedad

AU - Salamn, Israa

AU - Bufaroosha, Muna

AU - Zageer, Dheaa

AU - Yousif, Emad

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N2 - Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR,1H-NMR and119Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me2 SnL2 complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.

AB - Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR,1H-NMR and119Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me2 SnL2 complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.

KW - A549 cell line

KW - biological activity

KW - MTT assay

KW - Tin complex

KW - Valsartan

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CYTOTOXIC ACTIVITY AGAINST HUMAN LUNG CANCER CELL LINE (A549) OF DIMETHYL-TIN(IV) VALSARTAN COMPLEX

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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