CYTOTOXIC ACTIVITY AGAINST HUMAN LUNG CANCER CELL LINE (A549) OF DIMETHYL-TIN(IV) VALSARTAN COMPLEX

Alaa Mohammed, Muataz Ali, Wedad Al-Dahhan, Israa Salamn, Muna Bufaroosha, Dheaa Zageer, Emad Yousif

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR,1H-NMR and119Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me2 SnL2 complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalInternational Journal of Medical Toxicology and Legal Medicine
Volume25
Issue number3-4
DOIs
Publication statusPublished - Jul 1 2022

Keywords

  • A549 cell line
  • MTT assay
  • Tin complex
  • Valsartan
  • biological activity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology

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