TY - JOUR
T1 - Cytotoxic properties of fac-Re(CO)3 complexes with quinoline coligands
T2 - Insights on the mode of cell death and DNA fragmentation
AU - Abo-Elfadl, Mahmoud T.
AU - Mansour, Ahmed M.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Four tricarbonyl rhenium(I) complexes featuring quinoline ligands (1–4) were examined for their potential cytotoxicity properties against three malignant cell lines and one normal cell line of different origins. The most cytotoxic compound among the synthesized complexes was complex 2, which was formed when [ReBr(CO)3(N∧O)] (N∧O = quinoline-2-carboxaldehyde) (1) and para-amino phenol reacted. Its IC50 values are in the range of 26.05–30.33 μg/mL. Complex 4, decorated with benzimidazole moiety, has been demonstrated to be harmless to normal mice splenocytes. The cellular localization of 1–4 was investigated using fluorescence microscopy to provide insight into their biotargets, cellular localization, and modes of action. Among the evaluated malignant cell lines, complex 2 exhibited the highest levels of apoptotic and necrotic alterations in the MCF-7 cell line. Re(I) complexes appeared to gather inside intercellular connections and around cellular membranes, as seen in the fluorescence microscopy images. Along the cell membrane, the compounds accumulated as well, anticipating their entry.
AB - Four tricarbonyl rhenium(I) complexes featuring quinoline ligands (1–4) were examined for their potential cytotoxicity properties against three malignant cell lines and one normal cell line of different origins. The most cytotoxic compound among the synthesized complexes was complex 2, which was formed when [ReBr(CO)3(N∧O)] (N∧O = quinoline-2-carboxaldehyde) (1) and para-amino phenol reacted. Its IC50 values are in the range of 26.05–30.33 μg/mL. Complex 4, decorated with benzimidazole moiety, has been demonstrated to be harmless to normal mice splenocytes. The cellular localization of 1–4 was investigated using fluorescence microscopy to provide insight into their biotargets, cellular localization, and modes of action. Among the evaluated malignant cell lines, complex 2 exhibited the highest levels of apoptotic and necrotic alterations in the MCF-7 cell line. Re(I) complexes appeared to gather inside intercellular connections and around cellular membranes, as seen in the fluorescence microscopy images. Along the cell membrane, the compounds accumulated as well, anticipating their entry.
KW - Autofluorescence
KW - Cytotoxicity
KW - Quinoline ligands
KW - Rhenium(I) complexes
UR - http://www.scopus.com/inward/record.url?scp=85152899617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85152899617&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2023.121521
DO - 10.1016/j.ica.2023.121521
M3 - Article
AN - SCOPUS:85152899617
SN - 0020-1693
VL - 553
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
M1 - 121521
ER -