Cytotoxicity of fac-Mn(CO)3 complexes with a bidentate quinoline ligand towards triple negative breast cancer

Danira A. Habashy; Rabaa M. Khaled; Amr Y. Ahmed; Krzysztof Radacki; Salma K. Ahmed; Engy K. Tharwat; Hana Magdy; Alaa Zeinhom; Ahmed M. Mansour

doi:10.1039/d2dt01938h

Cytotoxicity of fac-Mn(CO)₃ complexes with a bidentate quinoline ligand towards triple negative breast cancer

Danira A. Habashy
, Rabaa M. Khaled
, Amr Y. Ahmed
, Krzysztof Radacki
, Salma K. Ahmed
, Engy K. Tharwat
, Hana Magdy
, Alaa Zeinhom
, Ahmed M. Mansour

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The cytotoxicity of two tricarbonyl Mn(i) complexes of the general formula fac-[MnBr(CO)₃L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.

Original language	English
Pages (from-to)	14041-14048
Number of pages	8
Journal	Dalton Transactions
Volume	51
Issue number	37
DOIs	https://doi.org/10.1039/d2dt01938h
Publication status	Published - Sept 15 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Inorganic Chemistry

Access to Document

10.1039/d2dt01938h

Cite this

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title = "Cytotoxicity of fac-Mn(CO)3 complexes with a bidentate quinoline ligand towards triple negative breast cancer",

abstract = "The cytotoxicity of two tricarbonyl Mn(i) complexes of the general formula fac-[MnBr(CO)3L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50\% reduction in cell viability.",

author = "Habashy, \{Danira A.\} and Khaled, \{Rabaa M.\} and Ahmed, \{Amr Y.\} and Krzysztof Radacki and Ahmed, \{Salma K.\} and Tharwat, \{Engy K.\} and Hana Magdy and Alaa Zeinhom and Mansour, \{Ahmed M.\}",

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doi = "10.1039/d2dt01938h",

language = "English",

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TY - JOUR

T1 - Cytotoxicity of fac-Mn(CO)3 complexes with a bidentate quinoline ligand towards triple negative breast cancer

AU - Habashy, Danira A.

AU - Khaled, Rabaa M.

AU - Ahmed, Amr Y.

AU - Radacki, Krzysztof

AU - Ahmed, Salma K.

AU - Tharwat, Engy K.

AU - Magdy, Hana

AU - Zeinhom, Alaa

AU - Mansour, Ahmed M.

PY - 2022/9/15

Y1 - 2022/9/15

N2 - The cytotoxicity of two tricarbonyl Mn(i) complexes of the general formula fac-[MnBr(CO)3L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.

AB - The cytotoxicity of two tricarbonyl Mn(i) complexes of the general formula fac-[MnBr(CO)3L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.

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DO - 10.1039/d2dt01938h

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