Cytotoxicity of photoactivatable tricarbonyl Mn(I) complex with 1-(chloromethyl)-1H-benzotriazole against leukaemia

Rabaa M. Khaled; Krzysztof Radacki; Sohaila A. Al-Abraq; Esraa El-Hussieny; Gamal A.E. Mostafa; Essam A. Ali; Ola R. Shehab; Ahmed M. Mansour

doi:10.1016/j.poly.2023.116574

Cytotoxicity of photoactivatable tricarbonyl Mn(I) complex with 1-(chloromethyl)-1H-benzotriazole against leukaemia

Rabaa M. Khaled
, Krzysztof Radacki
, Sohaila A. Al-Abraq
, Esraa El-Hussieny
, Gamal A.E. Mostafa
, Essam A. Ali
, Ola R. Shehab
, Ahmed M. Mansour

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH₂Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac-[MnBr(CO)₃(BTZ-CH₂Cl)₂]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells.

Original language	English
Article number	116574
Journal	Polyhedron
Volume	244
DOIs	https://doi.org/10.1016/j.poly.2023.116574
Publication status	Published - Nov 1 2023
Externally published	Yes

Keywords

Benzotriazole
Cell viability
Solvatochromism
Tricarbonyl manganese(I) complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.poly.2023.116574

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@article{865b212ae1a647d0a7127e371b8b0227,

title = "Cytotoxicity of photoactivatable tricarbonyl Mn(I) complex with 1-(chloromethyl)-1H-benzotriazole against leukaemia",

abstract = "The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH2Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac-[MnBr(CO)3(BTZ-CH2Cl)2]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells.",

keywords = "Benzotriazole, Cell viability, Solvatochromism, Tricarbonyl manganese(I) complexes",

author = "Khaled, \{Rabaa M.\} and Krzysztof Radacki and Al-Abraq, \{Sohaila A.\} and Esraa El-Hussieny and Mostafa, \{Gamal A.E.\} and Ali, \{Essam A.\} and Shehab, \{Ola R.\} and Mansour, \{Ahmed M.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = nov,

day = "1",

doi = "10.1016/j.poly.2023.116574",

language = "English",

volume = "244",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Cytotoxicity of photoactivatable tricarbonyl Mn(I) complex with 1-(chloromethyl)-1H-benzotriazole against leukaemia

AU - Khaled, Rabaa M.

AU - Radacki, Krzysztof

AU - Al-Abraq, Sohaila A.

AU - El-Hussieny, Esraa

AU - Mostafa, Gamal A.E.

AU - Ali, Essam A.

AU - Shehab, Ola R.

AU - Mansour, Ahmed M.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH2Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac-[MnBr(CO)3(BTZ-CH2Cl)2]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells.

AB - The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH2Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac-[MnBr(CO)3(BTZ-CH2Cl)2]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells.

KW - Benzotriazole

KW - Cell viability

KW - Solvatochromism

KW - Tricarbonyl manganese(I) complexes

UR - https://www.scopus.com/pages/publications/85167418173

UR - https://www.scopus.com/pages/publications/85167418173#tab=citedBy

U2 - 10.1016/j.poly.2023.116574

DO - 10.1016/j.poly.2023.116574

M3 - Article

AN - SCOPUS:85167418173

SN - 0277-5387

VL - 244

JO - Polyhedron

JF - Polyhedron

M1 - 116574

ER -

Cytotoxicity of photoactivatable tricarbonyl Mn(I) complex with 1-(chloromethyl)-1H-benzotriazole against leukaemia

Abstract

Keywords

ASJC Scopus subject areas

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