TY - JOUR
T1 - Dairy Milk Protein–Derived Bioactive Peptides
T2 - Avengers Against Metabolic Syndrome
AU - Koirala, Pankaj
AU - Dahal, Merina
AU - Rai, Sampurna
AU - Dhakal, Milan
AU - Nirmal, Nilesh Prakash
AU - Maqsood, Sajid
AU - Al-Asmari, Fahad
AU - Buranasompob, Athisaya
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/6
Y1 - 2023/6
N2 - Purpose of Review: Metabolic syndrome is continuously increasing among the world’s populations. Metabolic syndrome is a medical condition in which individuals suffer from high blood pressure, high blood glucose levels, and obesity. The in vitro and in vivo bioactivities of dairy milk protein–derived peptides (MPDP) have proven their potential as an excellent natural alternative to the current medical treatment for metabolic syndrome. In this context, the review discussed the major protein source of dairy milk and provides current knowledge on the novel and integrated approach to MPDP production. A detailed comprehensive discussion is provided on the current state of knowledge regarding the in vitro and in vivo bioactivities of MPDP against metabolic syndrome. In addition, the most important aspect of digestive stability, allergenicity, and further directions for MPDP application is provided. Recent Findings: The major proteins found in milk are casein and whey, while a minor portion of serum albumin and transferrin are reported. Upon gastrointestinal digestion or enzymatic hydrolysis, these proteins produce peptides with various biological activities including antioxidative, antiinflammatory, antihypertensive, antidiabetic, and antihypercholesterolemic, which could help in ameliorating metabolic syndrome. Summary: Bioactive MPDP has the potential to curtail metabolic syndrome and potentially act as a safe replacement for chemical drugs with fewer side effects.
AB - Purpose of Review: Metabolic syndrome is continuously increasing among the world’s populations. Metabolic syndrome is a medical condition in which individuals suffer from high blood pressure, high blood glucose levels, and obesity. The in vitro and in vivo bioactivities of dairy milk protein–derived peptides (MPDP) have proven their potential as an excellent natural alternative to the current medical treatment for metabolic syndrome. In this context, the review discussed the major protein source of dairy milk and provides current knowledge on the novel and integrated approach to MPDP production. A detailed comprehensive discussion is provided on the current state of knowledge regarding the in vitro and in vivo bioactivities of MPDP against metabolic syndrome. In addition, the most important aspect of digestive stability, allergenicity, and further directions for MPDP application is provided. Recent Findings: The major proteins found in milk are casein and whey, while a minor portion of serum albumin and transferrin are reported. Upon gastrointestinal digestion or enzymatic hydrolysis, these proteins produce peptides with various biological activities including antioxidative, antiinflammatory, antihypertensive, antidiabetic, and antihypercholesterolemic, which could help in ameliorating metabolic syndrome. Summary: Bioactive MPDP has the potential to curtail metabolic syndrome and potentially act as a safe replacement for chemical drugs with fewer side effects.
KW - Bioactivities
KW - Dairy milk
KW - Health benefits
KW - Metabolic syndrome
KW - Peptide
KW - Protein
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U2 - 10.1007/s13668-023-00472-1
DO - 10.1007/s13668-023-00472-1
M3 - Review article
C2 - 37204636
AN - SCOPUS:85159721535
SN - 2161-3311
VL - 12
SP - 308
EP - 326
JO - Current Nutrition Reports
JF - Current Nutrition Reports
IS - 2
ER -