Objective. To determine excess mortality among tuberculosis patients in the Netherlands and to identify risk factors for tuberculosis-associated mortality. Design. Cohort analysis. Methods. Of patients in whom tuberculosis was diagnosed in 1993-1995 and who were registered in the Nederlands Tuberculose Register mortality by age and sex was compared with national mortality rates. Risk factors were identified and adjustment for confounders was carried out using Cox' proportional hazard analysis. Results. Of 4340 patients alive at diagnosis, 258 died within one year while on treatment; 223 (86%) of deaths were attributed to causes other than tuberculosis. The Kaplan-Meier survival probability after one year was 93%. Tuberculosis patients had a standardised mortality ratio of 8.3. Of all deaths, 83% occurred in two risk groups comprising 21% of tuberculosis patients: those aged 65 years or more, and those having HIV infection or a malignancy. The probability of death (corrected for interrupted treatments) in these groups was 24% after one year. Conclusion. Tuberculosis patients in the Netherlands are at a considerably increased risk of death. However, the prognosis is good for those aged less than 65 years and without HIV infection or a malignancy.
|Translated title of the contribution||Death rate among tuberculosis patients in the Netherlands increased, especially among patients over 65 years, HIV-infected and patients with a malignancy|
|Number of pages||5|
|Journal||Nederlands Tijdschrift voor Geneeskunde|
|Publication status||Published - Mar 6 1999|
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