Defaulting from tuberculosis treatment in the Netherlands: Rates, risk factors and trend in the period 1993-1997

M. W. Borgdorff, J. Veen, N. A. Kalisvaart, J. F. Broekmans, N. J.D. Nagelkerke

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


The aim of this study was to assess the rate of defaulting from treatment among tuberculosis patients diagnosed in the Netherlands in the period 1993-1997, whether risk groups for defaulting can be identified at the start of treatment and the trend of defaulting over time. The Netherlands Tuberculosis Register provided data on all patients diagnosed in the Netherlands during the period 1993-1997. Defaulting probabilities were determined using Kaplan-Meier survival analysis and risk factors were identified with Cox's proportional hazard analysis. Of 7,529 patients with reported treatment outcome, 718 (10%) defaulted or left the country within 1 yr after starting treatment. Defaulting probabilities were 9% (95% confidence interval (CI) 8-10%) among 5,256 patients in low-risk groups, 17% (95% CI 14-19%) among 1,437 asylum seekers and 29% (95% CI 24-34%) among 836 patients in other high-risk groups (other recent immigrants, illegal immigrants, the homeless, prisoners and nationals from Eastern Europe). Defaulting probabilities decreased over time from 12% in 1993 to 7% in 1997. Risk groups for defaulting can be recognized at the start of treatment. The decreasing defaulting probabilities were probably due in part to shortening treatment from 9 to 6 months and improved follow-up of asylum seekers. However, additional measures are needed to reduce defaulting among the homeless, recent immigrants, illegal immigrants and prisoners.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalEuropean Respiratory Journal
Issue number2
Publication statusPublished - 2000
Externally publishedYes


  • Defaulting
  • Risk factors
  • Treatment interruption
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Defaulting from tuberculosis treatment in the Netherlands: Rates, risk factors and trend in the period 1993-1997'. Together they form a unique fingerprint.

Cite this