Degenerescence cerebelleuse secondaire a une intoxication aigue au lithium

Translated title of the contribution: Cerebellar denegeration following acute lithium intoxication

M. Roy, E. Stip, D. Black, V. Lew, R. Langlois

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Lithium is a neurotoxin with a particular affinity for the cerebellum. The risk of permanent neurotoxic sequelae of lithium is increased by the comcomitant use of certain conventional neuroleptics. We report two new cases of lithium neurotoxicity ; one received lithium alone, not in combination with a neuroleptic. Both cases showed severe cerebellar atrophy on brain CT and MRI. Additional factors such as dehydration, systemic infection, other medications, or rapid correction of frequently-coexisting hyponatremia may contribute to the risk of lithium neurotoxicity. We discuss possible pathophysiologic mechanisms and preventive measures.

Translated title of the contributionCerebellar denegeration following acute lithium intoxication
Original languageFrench
Pages (from-to)546-548
Number of pages3
JournalRevue Neurologique
Issue number6-7
Publication statusPublished - Jul 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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