Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

Derrick L.J. Clive, Soleiman Hisaindee, Don M. Coltart

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.

Original languageEnglish
Pages (from-to)9247-9254
Number of pages8
JournalJournal of Organic Chemistry
Volume68
Issue number24
DOIs
Publication statusPublished - Nov 28 2003
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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