Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

Derrick L.J. Clive; Soleiman Hisaindee; Don M. Coltart

doi:10.1021/jo030192r

Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

Derrick L.J. Clive
, Soleiman Hisaindee
, Don M. Coltart

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.

Original language	English
Pages (from-to)	9247-9254
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	68
Issue number	24
DOIs	https://doi.org/10.1021/jo030192r
Publication status	Published - Nov 28 2003
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo030192r

Cite this

@article{f99da35e769f4376b0d85ecf61d1bcfc,

title = "Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer",

abstract = "Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.",

author = "Clive, \{Derrick L.J.\} and Soleiman Hisaindee and Coltart, \{Don M.\}",

year = "2003",

month = nov,

day = "28",

doi = "10.1021/jo030192r",

language = "English",

volume = "68",

pages = "9247--9254",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

AU - Clive, Derrick L.J.

AU - Hisaindee, Soleiman

AU - Coltart, Don M.

PY - 2003/11/28

Y1 - 2003/11/28

N2 - Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.

AB - Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.

UR - https://www.scopus.com/pages/publications/0345686489

UR - https://www.scopus.com/pages/publications/0345686489#tab=citedBy

U2 - 10.1021/jo030192r

DO - 10.1021/jo030192r

M3 - Article

C2 - 14629143

AN - SCOPUS:0345686489

SN - 0022-3263

VL - 68

SP - 9247

EP - 9254

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 24

ER -

Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this