TY - JOUR
T1 - Detection of ascorbic acid based on its quenching effect on luminol-artemisinin chemiluminescence
AU - Wang, Chao
AU - Halawa, Mohamed Ibrahim
AU - Lou, Baohua
AU - Gao, Wenyue
AU - Li, Jianping
AU - Xu, Guobao
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2021/3/21
Y1 - 2021/3/21
N2 - We find that luminol can react with artemisinin (ART) to produce chemiluminescence (CL) in the absence of a catalyst and ascorbic acid (AA) can quench luminol-ART CL. Based on its efficient inhibition effect on luminol-ART CL, a new AA detection method is established. The calibration curve for the determination of AA is in the linear range of 5 × 10-7 M to 1 × 10-4 M with a detection limit of 50 nM, which is more sensitive than many other reported methods. This CL approach was utilized to detect AA in vitamin C tablets by applying the standard addition method, and the recoveries of 104.0%, 96.8% and 103.4% were obtained, respectively, at concentrations of 1 μM, 5 μM and 10 μM with a RSD value of less than 3.6%. This developed method for AA assay is distinguished by its fastness, reproducibility, easy operation and good selectivity.
AB - We find that luminol can react with artemisinin (ART) to produce chemiluminescence (CL) in the absence of a catalyst and ascorbic acid (AA) can quench luminol-ART CL. Based on its efficient inhibition effect on luminol-ART CL, a new AA detection method is established. The calibration curve for the determination of AA is in the linear range of 5 × 10-7 M to 1 × 10-4 M with a detection limit of 50 nM, which is more sensitive than many other reported methods. This CL approach was utilized to detect AA in vitamin C tablets by applying the standard addition method, and the recoveries of 104.0%, 96.8% and 103.4% were obtained, respectively, at concentrations of 1 μM, 5 μM and 10 μM with a RSD value of less than 3.6%. This developed method for AA assay is distinguished by its fastness, reproducibility, easy operation and good selectivity.
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U2 - 10.1039/d0an02280b
DO - 10.1039/d0an02280b
M3 - Article
C2 - 33502397
AN - SCOPUS:85102929600
SN - 0003-2654
VL - 146
SP - 1981
EP - 1985
JO - Analyst
JF - Analyst
IS - 6
ER -