TY - JOUR
T1 - Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence
AU - Leung, Chris Wai Tung
AU - Guo, Feng
AU - Hong, Yuning
AU - Zhao, Engui
AU - Kwok, Ryan Tsz Kin
AU - Leung, Nelson Lik Ching
AU - Chen, Sijie
AU - Vaikath, Nishant N.
AU - El-Agnaf, Omar Mukhtar
AU - Tang, Youhong
AU - Gai, Wei Ping
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2015.
PY - 2015/2/4
Y1 - 2015/2/4
N2 - We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
AB - We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
UR - http://www.scopus.com/inward/record.url?scp=84921506541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921506541&partnerID=8YFLogxK
U2 - 10.1039/c4cc07911f
DO - 10.1039/c4cc07911f
M3 - Article
C2 - 25526628
AN - SCOPUS:84921506541
SN - 1359-7345
VL - 51
SP - 1866
EP - 1869
JO - Chemical Communications
JF - Chemical Communications
IS - 10
ER -