Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

Chris Wai Tung Leung, Feng Guo, Yuning Hong, Engui Zhao, Ryan Tsz Kin Kwok, Nelson Lik Ching Leung, Sijie Chen, Nishant N. Vaikath, Omar Mukhtar El-Agnaf, Youhong Tang, Wei Ping Gai, Ben Zhong Tang

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.

Original languageEnglish
Pages (from-to)1866-1869
Number of pages4
JournalChemical Communications
Issue number10
Publication statusPublished - Feb 4 2015

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis


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