Detection of SARS-CoV-2 in COVID-19 Patient Nasal Swab Samples Using Signal Processing

Mahmoud Al Ahmad; Lillian J.A. Olule; Mohammed Meetani; Farrukh Amin Sheikh; Rahima Al Blooshi; Neena G. Panicker; Farah Mustafa; Tahir A. Rizvi

doi:10.1109/JSTSP.2021.3134073

Detection of SARS-CoV-2 in COVID-19 Patient Nasal Swab Samples Using Signal Processing

Mahmoud Al Ahmad, Lillian J.A. Olule, Mohammed Meetani, Farrukh Amin Sheikh, Rahima Al Blooshi, Neena G. Panicker, Farah Mustafa, Tahir A. Rizvi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.

Original language	English
Pages (from-to)	164-174
Number of pages	11
Journal	IEEE Journal on Selected Topics in Signal Processing
Volume	16
Issue number	2
DOIs	https://doi.org/10.1109/JSTSP.2021.3134073
Publication status	Published - Feb 1 2022

Keywords

COVID-19
SARS-CoV-2
light intensity
nucleocapsid protein
optical detection

ASJC Scopus subject areas

Signal Processing
Electrical and Electronic Engineering

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10.1109/JSTSP.2021.3134073

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title = "Detection of SARS-CoV-2 in COVID-19 Patient Nasal Swab Samples Using Signal Processing",

abstract = "This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.",

keywords = "COVID-19, SARS-CoV-2, light intensity, nucleocapsid protein, optical detection",

author = "Ahmad, {Mahmoud Al} and Olule, {Lillian J.A.} and Mohammed Meetani and Sheikh, {Farrukh Amin} and Blooshi, {Rahima Al} and Panicker, {Neena G.} and Farah Mustafa and Rizvi, {Tahir A.}",

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AU - Ahmad, Mahmoud Al

AU - Olule, Lillian J.A.

AU - Meetani, Mohammed

AU - Sheikh, Farrukh Amin

AU - Blooshi, Rahima Al

AU - Panicker, Neena G.

AU - Mustafa, Farah

AU - Rizvi, Tahir A.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.

AB - This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.

KW - COVID-19

KW - SARS-CoV-2

KW - light intensity

KW - nucleocapsid protein

KW - optical detection

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Detection of SARS-CoV-2 in COVID-19 Patient Nasal Swab Samples Using Signal Processing

Abstract

Keywords

ASJC Scopus subject areas

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