Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning

Subhabrata Bhattacharyya, Lakshmi S. Nair, Anurima Singh, Nick R. Krogman, Jared Bender, Yaser E. Greish, Paul W. Brown, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalConference articlepeer-review

19 Citations (Scopus)


Biodegradable polymeric nanofibers are of great interest as scaffolds for tissue engineering and drug delivery due to their extremely high surface area, high aspect ratio and similarity in structure to the extracellular matrix (ECM). Polyphosphazenes due to their synthetic flexibility, wide range of physico-chemical properties, non-toxic and neutral degradation products and excellent biocompatibility are suitable candidates for biomedical applications. The objective of the present study was to develop and evaluate composite nanofibers of a biodegradable polyphosphazene, poly[bis(ethyl alanato)phosphazene] (PNEA) and nanocrystals of hydroxyapatite (nHAp) via electrospinning. A suspension of nHAp in dimethyl formamide (DMF) sonicated with PNEA solution in tetrahydrofuran (THF) was used to develop composite nanofiber matrices via electrospinning at ambient conditions. In the present study the theoretical loading of nHAp was varied from 50%-90% (w/w) to PNEA. The nHAp content (actual loading of nHAp) of the composite nanofibers was determined by gravimetric estimation. The composite nanofibers were characterized by transmission electron microscopy (TEM), gravimetry and energy dispersive X-ray mapping. This study demonstrated the feasibility of developing novel composite nanofibers of biodegradable polyphosphazenes with more than 50% (w/w) loading of nHAp on and within the nanofibers.

Original languageEnglish
Article numberAA4.2
Pages (from-to)91-96
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Publication statusPublished - 2005
Externally publishedYes
EventNanoscale Materials Science in Biology and Medicine - Boston, MA, United States
Duration: Nov 28 2004Dec 2 2004


  • Bone tissue engineering
  • Electrospinning
  • Nanofiber
  • Nanohydroxyapatite
  • Polyphosphazenes

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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