TY - JOUR
T1 - Dexamethasone-induced increase in the rate of appearance in plasma of gut-derived glucose following an oral glucose load in rats
AU - Stojanovska, L.
AU - Rosella, G.
AU - Proietto, J.
N1 - Funding Information:
From the Department of Medicine, Universir?,o f Melbourne, Royal Melbourne Hospital, Park&e, Australia. Supported by a program grant from the National Health and Medical Research Council of Australia. J.P. is a Wellcome Australia Senior Research Fellow. Address reprint requests to .I. Proietto, MD, Department of Medicine, Royal Melbourne Hospital, Parkville 3050. Australia. Copyright 0 1991 by W.B. Saunders Cornpan? 0026049519114003-0014$03.OOlO
PY - 1991/3
Y1 - 1991/3
N2 - Glucocorticoids are known to impair oral glucose tolerance and to induce insulin resistance. It has also been reported that glucocorticoids stimulate absorption of glucose, water, and electrolytes from the gut. The aim of the present study was to determine if dexamethasone treatment increased the rate of appearance in plasma of gut-derived glucose. Glucose turnover was measured following an oral glucose load in chronically catheterized, nonstressed rats treated for 96 hours with either normal saline (n = 14) or dexamethasone (5 μg twice daily intravenously [IV]) (n = 10). Dexamethasone-treated rats had mild glucose intolerance and higher insulin levels than control rats. Total glucose turnover was increased at all time points following the glucose drink in the dexamethasone-treated rats, as was the rate of appearance of gut-derived glucose (154 ± 25 v 321 ± 62 mg 45 min; P = .018). It is concluded that in rats, dexamethasone treatment increases the rate of appearance in plasma of orally administered glucose.
AB - Glucocorticoids are known to impair oral glucose tolerance and to induce insulin resistance. It has also been reported that glucocorticoids stimulate absorption of glucose, water, and electrolytes from the gut. The aim of the present study was to determine if dexamethasone treatment increased the rate of appearance in plasma of gut-derived glucose. Glucose turnover was measured following an oral glucose load in chronically catheterized, nonstressed rats treated for 96 hours with either normal saline (n = 14) or dexamethasone (5 μg twice daily intravenously [IV]) (n = 10). Dexamethasone-treated rats had mild glucose intolerance and higher insulin levels than control rats. Total glucose turnover was increased at all time points following the glucose drink in the dexamethasone-treated rats, as was the rate of appearance of gut-derived glucose (154 ± 25 v 321 ± 62 mg 45 min; P = .018). It is concluded that in rats, dexamethasone treatment increases the rate of appearance in plasma of orally administered glucose.
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U2 - 10.1016/0026-0495(91)90113-B
DO - 10.1016/0026-0495(91)90113-B
M3 - Article
C2 - 2000043
AN - SCOPUS:0026028068
SN - 0026-0495
VL - 40
SP - 297
EP - 301
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -