TY - JOUR
T1 - Dielectrophoretic 3D-focusing for on-chip flow cytometry
AU - Krishna, Salini
AU - Alnaimat, Fadi
AU - Al Naqbi, Ali Abdullah Hilal
AU - Khashan, Saud Abdelaziz
AU - Mathew, Bobby
N1 - Funding Information:
6. Acknowledgment: This work was supported by UAEU (grant no. 31N264).
Publisher Copyright:
© The Institution of Engineering and Technology 2020
PY - 2020/4/22
Y1 - 2020/4/22
N2 - Model-based analysis of a dielectrophoretic microfluidic device for realising 3D-focusing is presented in this work. The electrode configuration is made up of several finite-sized planar electrodes positioned on either side of the microchannel’s top and bottom surfaces; the electrodes on the top surface and bottom surface of the same side form a pair. The forces associated with inertia, buoyancy, gravity, and dielectrophoresis are included in the model. As per the model, it is possible to use the proposed device to achieve 3D-focusing at the desired location along the width of the microchannel. Also, the proposed device can achieve 3D-focusing irrespective of the type of micro-scale entity. Two parameters for quantifying the efficacy of the microfluidic device in achieving 3D-focusing are presented – horizontal and vertical focusing parameters. The model demonstrates that the radius of micro-scale entity, electrode/gap lengths, electrode width, microchannel height, number of electrodes, applied electric potentials, and volumetric flow rate influence horizontal and vertical focusing parameters. The mathematical model is thus useful in designing dielectrophoresis-based 3D-focusing with desired performance metrics for on-chip flow cytometry.
AB - Model-based analysis of a dielectrophoretic microfluidic device for realising 3D-focusing is presented in this work. The electrode configuration is made up of several finite-sized planar electrodes positioned on either side of the microchannel’s top and bottom surfaces; the electrodes on the top surface and bottom surface of the same side form a pair. The forces associated with inertia, buoyancy, gravity, and dielectrophoresis are included in the model. As per the model, it is possible to use the proposed device to achieve 3D-focusing at the desired location along the width of the microchannel. Also, the proposed device can achieve 3D-focusing irrespective of the type of micro-scale entity. Two parameters for quantifying the efficacy of the microfluidic device in achieving 3D-focusing are presented – horizontal and vertical focusing parameters. The model demonstrates that the radius of micro-scale entity, electrode/gap lengths, electrode width, microchannel height, number of electrodes, applied electric potentials, and volumetric flow rate influence horizontal and vertical focusing parameters. The mathematical model is thus useful in designing dielectrophoresis-based 3D-focusing with desired performance metrics for on-chip flow cytometry.
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U2 - 10.1049/mnl.2019.0404
DO - 10.1049/mnl.2019.0404
M3 - Article
AN - SCOPUS:85083895617
SN - 1750-0443
VL - 15
SP - 296
EP - 301
JO - Micro and Nano Letters
JF - Micro and Nano Letters
IS - 5
ER -