Distributional independent component analysis for diverse neuroimaging modalities

Ben Wu, Subhadip Pal, Jian Kang, Ying Guo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Recent advances in neuroimaging technologies have provided opportunities to acquire brain images of different modalities for studying human brain organization from both functional and structural perspectives. Analysis of images derived from various modalities involves some common goals such as dimension reduction, denoising, and feature extraction. However, since these modalities have vastly different data characteristics, the current analysis is usually performed using distinct analytical tools that are only suitable for a specific imaging modality. In this paper, we present a Distributional Independent Component Analysis (DICA) that represents a new approach that performs decomposition on the distribution level, providing a unified framework for extracting features across imaging modalities with different scales and representations. When applying DICA to fMRI images, we successfully recover well-established brain functional networks in neuroscience literature, providing empirical validation that DICA delivers neurologically relevant findings. More importantly, we discover several structural network components when applying DICA to DTI images. Through fiber tracking, we find these DICA-derived structural components correspond to several major white fiber bundles. To the best of our knowledge, this is the first time these fiber bundles are successfully identified via blind source separation on single subject DTI images. We also evaluate the performance of DICA as compared with existing ICA methods through extensive simulation studies.

Original languageEnglish
Pages (from-to)1092-1105
Number of pages14
Issue number3
Publication statusPublished - Sept 1 2022
Externally publishedYes


  • DTI
  • fMRI
  • independent component analysis
  • multimodality neuroimaging

ASJC Scopus subject areas

  • Statistics and Probability
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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