DNA bases detection via MoS2 field effect transistor with a nanopore: first-principles modeling

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2 Citations (Scopus)


Recently, molybdenum disulfide (MoS2) has captured vast interest in the biomolecular detection field because of its wide surface area and notable optoelectronic characteristics. In this work, a monolayer MoS2 sheet connected to a pair of gold electrodes, with a nanopore at the center of the MoS2 sheet, is designed for the purpose of selective, quick, and sensitive DNA base identification. The MoS2 sheet performance is enhanced by placing a gate terminal underneath the MoS2 channel. MoS2 material has various promising applications and can be utilized in multi terminal sensors. The electronic transport characteristics of the MoS2 sheet and the MoS2 field effect transistor after placing each of the DNA nucleobases inside the pore are studied. Both MoS2 sheet and MoS2 FET sensors exhibit distinct electronic characteristics for the different DNA nucleobases (Thymine, Adenine, Cytosine, and Guanine). Density functional theory integrated with Non-equilibrium Green’s function (DFT + NEGF) are used to inspect the detection mechanism.

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalAnalog Integrated Circuits and Signal Processing
Issue number2
Publication statusPublished - Feb 2023


  • DNA sequencing
  • Density functional theory
  • Electronic properties
  • FET
  • FET
  • Molybdenum disulfide (MoS)
  • Nanopore

ASJC Scopus subject areas

  • Signal Processing
  • Hardware and Architecture
  • Surfaces, Coatings and Films


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