@inbook{3377bb053bc0418c83b784577adef1da,
title = "DNA methylation in the pathogenesis of type 2 diabetes",
abstract = "Type 2 diabetes (T2D) is a metabolic disease characterized by the development of β-cell dysfunction with hepatic, muscular and adipose tissue insulin resistance. Although the molecular mechanisms leading to its development are not entirely known, investigations of its causes reveal a multifactorial contribution to its development and progression in most cases. In addition, regulatory interactions mediated by epigenetic modifications such as DNA methylation, histone tail modifications and regulatory RNAs have been found to play a significant role in the etiology of T2D. In this chapter, we discuss the role of DNA methylation and its dynamics in the development of the pathological features of T2D.",
keywords = "DNA methylation, Epigenetic modifications, Glucose, Insulin resistance, Metabolic diseases, Type 2 diabetes",
author = "Suneesh Kaimala and Ansari, {Suraiya Anjum} and Emerald, {Bright Starling}",
note = "Funding Information: Work in the lab of BSE is supported by research grants from United Arab Emirates University, UAEU-IIT collaborative grant 31M492/12M053, Zayed Center for Health Sciences grant #31R228, AUA-Zayed Center grant #12R120 and Strategic Research Program-Zayed Center grant #12R110. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = jan,
doi = "10.1016/bs.vh.2022.11.002",
language = "English",
isbn = "9780443158186",
series = "Vitamins and Hormones",
publisher = "Academic Press Inc.",
pages = "147--169",
editor = "Gerald Litwack",
booktitle = "Hormones and Epigenetics",
address = "United States",
}
