DNA methylation in the pathogenesis of type 2 diabetes

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Type 2 diabetes (T2D) is a metabolic disease characterized by the development of β-cell dysfunction with hepatic, muscular and adipose tissue insulin resistance. Although the molecular mechanisms leading to its development are not entirely known, investigations of its causes reveal a multifactorial contribution to its development and progression in most cases. In addition, regulatory interactions mediated by epigenetic modifications such as DNA methylation, histone tail modifications and regulatory RNAs have been found to play a significant role in the etiology of T2D. In this chapter, we discuss the role of DNA methylation and its dynamics in the development of the pathological features of T2D.

Original languageEnglish
Title of host publicationHormones and Epigenetics
EditorsGerald Litwack
PublisherAcademic Press Inc.
Pages147-169
Number of pages23
ISBN (Print)9780443158186
DOIs
Publication statusPublished - Jan 2023

Publication series

NameVitamins and Hormones
Volume122
ISSN (Print)0083-6729

Keywords

  • DNA methylation
  • Epigenetic modifications
  • Glucose
  • Insulin resistance
  • Metabolic diseases
  • Type 2 diabetes

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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