Abstract
Type 2 diabetes (T2D) is a metabolic disease characterized by the development of β-cell dysfunction with hepatic, muscular and adipose tissue insulin resistance. Although the molecular mechanisms leading to its development are not entirely known, investigations of its causes reveal a multifactorial contribution to its development and progression in most cases. In addition, regulatory interactions mediated by epigenetic modifications such as DNA methylation, histone tail modifications and regulatory RNAs have been found to play a significant role in the etiology of T2D. In this chapter, we discuss the role of DNA methylation and its dynamics in the development of the pathological features of T2D.
| Original language | English |
|---|---|
| Title of host publication | Hormones and Epigenetics |
| Editors | Gerald Litwack |
| Publisher | Academic Press Inc. |
| Pages | 147-169 |
| Number of pages | 23 |
| ISBN (Print) | 9780443158186 |
| DOIs | |
| Publication status | Published - Jan 2023 |
Publication series
| Name | Vitamins and Hormones |
|---|---|
| Volume | 122 |
| ISSN (Print) | 0083-6729 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- DNA methylation
- Epigenetic modifications
- Glucose
- Insulin resistance
- Metabolic diseases
- Type 2 diabetes
ASJC Scopus subject areas
- Physiology
- Endocrinology
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