@article{22cbe23eabcd494782332b64cd2b756f,
title = "Dose-dependent tissue distribution of K117, a bis-pyridinium aldoxime, in rats",
abstract = "Background: Bis-pyridinium aldoximes are reactivators of the paraoxon-inhibited butyrylcholinesterase enzyme. Paraoxon is the active product of parathion, a widely used insecticide. Objective: The objective of this study is to examine the dose-dependent distribution of K117, a bis-pyridinium aldoxime in rat tissues. Materials and Methods: White male Wistar rats were intramuscularly injected with various doses of K117; the animals were sacrificed 30 minutes after injections. The dose-dependent body distribution of K117 was determined using reversed-phase HPLC. Results: Dose-dependent distribution of K117 in body tissues was linear in the serum and other body tissues throughout the whole range of the concentrations studied. However, the of distribution was not observed in the brain and cerebrospinal fluid, especially with high doses. Conclusion: The body distribution of K117 significantly depends on doses used, the p-value is: 500 nmol, i.m., when applied in the range of 100 to 10,000 nmol.",
keywords = "Dose-dependence, Intramuscular injections, K117, Linear pattern, Pharmacokinetics, Wistar rats",
author = "Huba Kal{\'a}sz and Gell{\'e}rt Karvaly and Kamil Musilek and Kamil Kuca and Jung Young-Sik and Barbara Malawska and Adeghate, {Ernest A.} and Nurulain, {Syed M.} and Judit Szepesy and Tibor Zelles and Korn{\'e}lia Tekes",
note = "Funding Information: This project is based on a Corsorcium Agreement between Korea Research Institute (Daejeon, Korea), Jagiellonian University (Krakow, Poland), University of Hradec Kralove (Hradec Kralove, Czech Republic) and Semmelweis University (Budapest, Hungary). The authors express their thanks to Mr. J{\'a}nos Horv{\'a}th and Ms. Bogi Szalacsi for their advice. Technical assistance was provided by Ms. Gy{\"o}rgyike Guth, Ms. Krisztina Kecsk{\'e}s, Mr. Zolt{\'a}n Szimr{\'o}k and Mr. Andr{\'a}s Keglevich. This project was financially supported by the grant NN126968 of National Research, Development and Innovation Office (NRDIO, Budapest, Hungary) this research was supported by Ministry of Education, Youth and Sports of the Czech Republic (No. 8F17004) via V4-Korea Joint Research Program and also by Kal{\'a}sz Teaching and Research Co. (Budapest, Hungary). Grant No. K128875 of NRDIO served as partial source of salary to JSz. Funding Information: This project was financially supported by the grant NN126968 of National Research, Development and Innovation Office (NRDIO, Budapest, Hungary) this research was supported by Ministry of Education, Youth and Sports of the Czech Republic (No. 8F17004) via V4-Korea Joint Research Program and also by Kal{\'a}sz Teaching and Research Co. (Budapest, Hungary). Grant No. K128875 of NRDIO served as partial source of salary to JSz. Publisher Copyright: {\textcopyright} 2019 Kal{\'a}sz et al.",
year = "2019",
doi = "10.2174/1874104501913010001",
language = "English",
volume = "13",
pages = "1--6",
journal = "Open Medicinal Chemistry Journal",
issn = "1874-1045",
publisher = "Bentham Science Publishers B.V.",
number = "1",
}