Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

Tasneem Shamsi Basha; Amina Bakro; Hari Pankaj Vanam; Akela Ghazawi; Areej AlGhamdi; Fatima Al Dhaheri

doi:10.1016/j.mmcr.2025.100735

Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

Tasneem Shamsi Basha
, Amina Bakro
, Hari Pankaj Vanam
, Akela Ghazawi
, Areej AlGhamdi
, Fatima Al Dhaheri

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

Original language	English
Article number	100735
Journal	Medical Mycology Case Reports
Volume	50
DOIs	https://doi.org/10.1016/j.mmcr.2025.100735
Publication status	Published - Dec 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aspergillus flavus
Candida parapsilosis
End-stage renal disease (ESRD) conflict-zone healthcare
Fungal endocarditis
Pediatric hemodialysis

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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10.1016/j.mmcr.2025.100735

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title = "Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection",

abstract = "We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.",

keywords = "Aspergillus flavus, Candida parapsilosis, End-stage renal disease (ESRD) conflict-zone healthcare, Fungal endocarditis, Pediatric hemodialysis",

author = "Basha, \{Tasneem Shamsi\} and Amina Bakro and Vanam, \{Hari Pankaj\} and Akela Ghazawi and Areej AlGhamdi and \{Al Dhaheri\}, Fatima",

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doi = "10.1016/j.mmcr.2025.100735",

language = "English",

volume = "50",

journal = "Medical Mycology Case Reports",

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TY - JOUR

T1 - Dual fungal endocarditis in a pediatric dialysis patient

T2 - First case of Aspergillus flavus and Candida parapsilosis co-infection

AU - Basha, Tasneem Shamsi

AU - Bakro, Amina

AU - Vanam, Hari Pankaj

AU - Ghazawi, Akela

AU - AlGhamdi, Areej

AU - Al Dhaheri, Fatima

PY - 2025/12

Y1 - 2025/12

N2 - We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

AB - We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

KW - Aspergillus flavus

KW - Candida parapsilosis

KW - End-stage renal disease (ESRD) conflict-zone healthcare

KW - Fungal endocarditis

KW - Pediatric hemodialysis

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DO - 10.1016/j.mmcr.2025.100735

M3 - Article

AN - SCOPUS:105016475786

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VL - 50

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

M1 - 100735

ER -

Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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