Abstract
In this study, we provide a fractional-order mathematical model that considers the effect of vaccination on COVID-19 spread dynamics. The model accounts for the latent period of intervention strategies by incorporating a time delay (Formula presented.). A basic reproduction number, (Formula presented.), is determined for the model, and prerequisites for endemic equilibrium are discussed. The model’s endemic equilibrium point also exhibits local asymptotic stability (under certain conditions), and a Hopf bifurcation condition is established. Different scenarios of vaccination efficacy are simulated. As a result of the vaccination efforts, the number of deaths and those affected have decreased. COVID-19 may not be effectively controlled by vaccination alone. To control infections, several non-pharmacological interventions are necessary. Based on numerical simulations and fitting to real observations, the theoretical results are proven to be effective.
| Original language | English |
|---|---|
| Article number | 758 |
| Journal | Vaccines |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2023 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- COVID-19
- bifurcation
- fractional-order
- stability
- time-delay
- vaccination
ASJC Scopus subject areas
- Immunology
- Pharmacology
- Drug Discovery
- Infectious Diseases
- Pharmacology (medical)
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