@inproceedings{95cb5297dac34890bbf9e0872c1931bd,
title = "Dynamics of hepatitis C virus infection",
abstract = "Herein, we provide a mathematical model to investigate the dynamics of Hepatitis-C Virus (HCV) replication, in presence of interferon-α (IFN) treatment. We consider a fractional-order in the model to represent the intermediate cellular interactions and intracellular delay of the viral life cycle. We analyze the steady states and dynamical behavior of the model. We deduce a threshold parameter R0 (average number of newly infected cells produced by a single infected cell) in terms of the treatment efficacy parameter 0 ≤ ϵ < 1 and other parameters. The suggested model has the ability to provide accurate descriptions of nonlinear biological systems with memory. The obtained results give an insight to understand the dynamics of HCV infection.",
keywords = "Hepatitis C virus, Interferon-α, Mathematical modeling, Stability, Viral dynamics",
author = "Rihan, {Fathalla A.} and Rihan, {Bassel F.}",
note = "Publisher Copyright: {\textcopyright} 2018 ISCA, BICOB.; 10th International Conference on Bioinformatics and Computational Biology, BICOB 2018 ; Conference date: 19-03-2018 Through 21-03-2018",
year = "2018",
language = "English",
series = "Proceedings of the 10th International Conference on Bioinformatics and Computational Biology, BICOB 2018",
publisher = "The International Society for Computers and Their Applications (ISCA)",
editor = "Hisham Al-Mubaid and Oliver Eulenstein and Qin Ding",
booktitle = "Proceedings of the 10th International Conference on Bioinformatics and Computational Biology, BICOB 2018",
}