Early studies on DNA-based immunizations for measles virus

K. Yang; F. Mustafa; A. Valsamakis; J. C. Santoro; D. E. Griffin; H. L. Robinson

doi:10.1016/S0264-410X(96)00261-7

Early studies on DNA-based immunizations for measles virus

K. Yang, F. Mustafa, A. Valsamakis, J. C. Santoro, D. E. Griffin, H. L. Robinson

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.

Original language	English
Pages (from-to)	888-891
Number of pages	4
Journal	Vaccine
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/S0264-410X(96)00261-7
Publication status	Published - Jun 1997
Externally published	Yes

Keywords

DNA vaccines
Measles fusion protein
Measles hemagglutinin
Measles vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(96)00261-7

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title = "Early studies on DNA-based immunizations for measles virus",

abstract = "DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.",

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T1 - Early studies on DNA-based immunizations for measles virus

AU - Yang, K.

AU - Mustafa, F.

AU - Valsamakis, A.

AU - Santoro, J. C.

AU - Griffin, D. E.

AU - Robinson, H. L.

PY - 1997/6

Y1 - 1997/6

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AB - DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.

KW - DNA vaccines

KW - Measles fusion protein

KW - Measles hemagglutinin

KW - Measles vaccine

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Early studies on DNA-based immunizations for measles virus

Abstract

Keywords

ASJC Scopus subject areas

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