SYSTEMISCHE FRUHLYSE DES AKUTEN MYOKARDINFARKTS. VERGLEICH ZWISCHEN KLINIK UND PRAHOSPITALPHASE

Translated title of the contribution: Early systemic thrombolysis of acute myocardial infarction: Comparison between pre- and intra-hospital treatment

U. Martens, P. Lange-Braun, R. Langer, H. Hochrein

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Short-term systemic thrombolytic treatment was undertaken in 84 patients - within the first three hours after onset of pain; with typical ECG signs of acute transmural myocardial infarction; refractory to nitroglycerine - either in an intensive care unit (n = 40) or in a medically-staffed ambulance (n = 44). Coronary angiography was undertaken in patients of both groups, after obtaining informed consent, at the earliest possible moments, combined with percutaneous transluminal coronary angioplasty (PTCA), if indicated. Thrombolytic treatment in the ambulance was primarily more effective (72%, n = 32) than in the ICU patients (47.5%; n = 19), and the pain-thrombolysis interval shorter by 30 min. The higher recurrent infarction rate in the former meant that the success rate at the end of the hospital stay did not significantly differ between the two groups (54.5% and 47.5%, respectively). Only when early systemic thrombolysis was combined with PTCA within the first three hours (n = 26) was there a markedly greater effectiveness after four weeks (77%) than without PTCA (40%). Early thrombolytic treatment by doctors in the ambulance during transfer to hospital is sensible only if it can be followed at once by coronary angiography with PTCA or operation soon after admission. Only in this way will the effectiveness of treatment be increased and maintained after discharge from hospital.

Translated title of the contributionEarly systemic thrombolysis of acute myocardial infarction: Comparison between pre- and intra-hospital treatment
Original languageGerman
Pages (from-to)910-914
Number of pages5
JournalDeutsche Medizinische Wochenschrift
Volume112
Issue number23
DOIs
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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