Effect of Commiphora mukul extract on cardiac dysfunction and ventricular function in isoproterenol-induced myocardial infarction

Shreesh K. Ojha, Mukesh Nandave, Sachin Arora, Raj D. Mehra, Sujata Joshi, Rajiv Narang, D. S. Arya

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

In present study, hydroalcoholic extract of C. mukul significantly improved the cardiac function and prevented myocardial ischemic impairment manifested in the form of increased heart rate, decreased arterial pressure, increased left ventricular end diastolic pressure, and altered myocardial contractility indices. C. mukul treatment additionally also produced a significant increase in lactate dehydrogenase levels and prevented decline of protein content in heart. C. mukul preserved the structural integrity of myocardium. Reduced leakage of myocyte enzyme lactate dehydrogenase and maintenance of structural integrity of myocardium along with favorable modulation of cardiac function and improved cardiac performance indicate the salvage of myocardium with C. mukul treatment. Guggulsterones which are considered to be responsible for most of the therapeutic properties of C. mukul may underlie the observed cardioprotective effect of C. mukul against cardiac dysfunction in isoproterenol-induced ischemic rats.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalIndian Journal of Experimental Biology
Volume46
Issue number9
Publication statusPublished - Sept 2008
Externally publishedYes

Keywords

  • Cardiac function
  • Commiphora mukul
  • Guggul
  • Isoproterenol
  • Ventricular function

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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