TY - JOUR
T1 - Effect of duodenal switch procedure on gastric acid production, intragastric pH, gastric emptying, and gastrointestinal hormones
AU - Welch, Neil T.
AU - Yasui, Akihiro
AU - Kim, Choong B.
AU - Barlow, Antony P.
AU - Hinder, Ronald A.
AU - DeMeeSter, Tom R.
AU - Polishuk, Paul V.
AU - Clark, Geoffrey W.B.
AU - Adrian, Thomas E.
N1 - Funding Information:
From the Departments of Surgery (NTW, AY, CBK, APB, RAH, PVP, CWBC) and Biomedical Sciences (TEA), Creighton University School of Medicine, Omaha, Nebraska, and the Department of Surgery (TRD), University of Southern California, Los Angeles, California. Supported by PHS Grant fRO1 DK 40381 OlAl SB. keque& for reprints ihould be addressed to Ronald A. Hinder. MD, FACS, Creighton University School of Medicine, Department of Surgery, -_ 601 North 30th Street. Omaha. Nebraska 68131. Presented at the 32nd Annual Meeting of the Society for Surgery of the Alimentary Tract, New Orleans, Louisiana, May 20-22,199l.
PY - 1992/1
Y1 - 1992/1
N2 - The duodenal switch operation preserves the pylorus and the proximal 3 to 7 cm of duodenum in continuity with the stomach while diverting pancreaticobiliary secretions. We compared it with the Roux-en-Y without vagotomy or antrectomy in 12 dogs with innervated gastric pouches. Acid secretion was inhibited between tests using ranitidine in the Roux-en-Y group only, but two of the six dogs still developed stomal ulcers and the remainder showed stomal hyperemia. This may be due to a significant increase in gastric acid output after Roux-en-Y, but gastric emptying and plasma gastrin, cholecystokinin, secretin, gastric inhibitory polypeptide, peptide YY, and neurotensin were similar after both procedures. In 12 patients and a further 6 dogs, the duodenal switch caused no significant change in the intragastric pH environment as assessed by intragastric pH monitoring. The duodenal switch is a suitable procedure for pancreaticobiliary diversion.
AB - The duodenal switch operation preserves the pylorus and the proximal 3 to 7 cm of duodenum in continuity with the stomach while diverting pancreaticobiliary secretions. We compared it with the Roux-en-Y without vagotomy or antrectomy in 12 dogs with innervated gastric pouches. Acid secretion was inhibited between tests using ranitidine in the Roux-en-Y group only, but two of the six dogs still developed stomal ulcers and the remainder showed stomal hyperemia. This may be due to a significant increase in gastric acid output after Roux-en-Y, but gastric emptying and plasma gastrin, cholecystokinin, secretin, gastric inhibitory polypeptide, peptide YY, and neurotensin were similar after both procedures. In 12 patients and a further 6 dogs, the duodenal switch caused no significant change in the intragastric pH environment as assessed by intragastric pH monitoring. The duodenal switch is a suitable procedure for pancreaticobiliary diversion.
UR - https://www.scopus.com/pages/publications/0026590659
UR - https://www.scopus.com/pages/publications/0026590659#tab=citedBy
U2 - 10.1016/0002-9610(92)90250-U
DO - 10.1016/0002-9610(92)90250-U
M3 - Article
C2 - 1733373
AN - SCOPUS:0026590659
SN - 0002-9610
VL - 163
SP - 37
EP - 45
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 1
ER -