Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses

Renato Sobral Monteiro-Junior; Paulo De Tarso Maciel-Pinheiro; Eduardo Da Matta Mello Portugal; Luiz Felipe Da Silva Figueiredo; Rodrigo Terra; Lara S.F. Carneiro; Vinícius Dias Rodrigues; Osvaldo J.M. Nascimento; Andrea Camaz Deslandes; Jerson Laks

doi:10.1123/jpah.2016-0735

Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses

Renato Sobral Monteiro-Junior
, Paulo De Tarso Maciel-Pinheiro
, Eduardo Da Matta Mello Portugal
, Luiz Felipe Da Silva Figueiredo
, Rodrigo Terra
, Lara S.F. Carneiro
, Vinícius Dias Rodrigues
, Osvaldo J.M. Nascimento
, Andrea Camaz Deslandes
, Jerson Laks

Research output: Contribution to journal › Review article › peer-review

100 Citations (Scopus)

Abstract

Background: Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. Purpose: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons. Methods: Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect. Results: Seventysix studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05). Conclusion: Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.

Original language	English
Pages (from-to)	64-71
Number of pages	8
Journal	Journal of Physical Activity and Health
Volume	15
Issue number	1
DOIs	https://doi.org/10.1123/jpah.2016-0735
Publication status	Published - Jan 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aging
Gerontology
Physical activity

ASJC Scopus subject areas

Epidemiology
Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation
Public Health, Environmental and Occupational Health

Access to Document

10.1123/jpah.2016-0735

Cite this

Monteiro-Junior, R. S., De Tarso Maciel-Pinheiro, P., Da Matta Mello Portugal, E., Da Silva Figueiredo, L. F., Terra, R., Carneiro, L. S. F., Rodrigues, V. D., Nascimento, O. J. M., Deslandes, A. C., & Laks, J. (2018). Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses. Journal of Physical Activity and Health, 15(1), 64-71. https://doi.org/10.1123/jpah.2016-0735

Monteiro-Junior, RS, De Tarso Maciel-Pinheiro, P, Da Matta Mello Portugal, E, Da Silva Figueiredo, LF, Terra, R, Carneiro, LSF, Rodrigues, VD, Nascimento, OJM, Deslandes, AC & Laks, J 2018, 'Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses', Journal of Physical Activity and Health, vol. 15, no. 1, pp. 64-71. https://doi.org/10.1123/jpah.2016-0735

@article{ddfe88943afd4bbea2b4cfe4f422bdec,

title = "Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses",

abstract = "Background: Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. Purpose: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons. Methods: Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect. Results: Seventysix studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05). Conclusion: Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.",

keywords = "Aging, Gerontology, Physical activity",

author = "Monteiro-Junior, \{Renato Sobral\} and \{De Tarso Maciel-Pinheiro\}, Paulo and \{Da Matta Mello Portugal\}, Eduardo and \{Da Silva Figueiredo\}, \{Luiz Felipe\} and Rodrigo Terra and Carneiro, \{Lara S.F.\} and Rodrigues, \{Vin{\'i}cius Dias\} and Nascimento, \{Osvaldo J.M.\} and Deslandes, \{Andrea Camaz\} and Jerson Laks",

note = "Publisher Copyright: {\textcopyright} 2018 Human Kinetics, Inc.",

year = "2018",

month = jan,

doi = "10.1123/jpah.2016-0735",

language = "English",

volume = "15",

pages = "64--71",

journal = "Journal of Physical Activity and Health",

issn = "1543-3080",

publisher = "Human Kinetics Publishers Inc.",

number = "1",

}

TY - JOUR

T1 - Effect of exercise on inflammatory profile of older persons

T2 - Systematic review and meta-analyses

AU - Monteiro-Junior, Renato Sobral

AU - De Tarso Maciel-Pinheiro, Paulo

AU - Da Matta Mello Portugal, Eduardo

AU - Da Silva Figueiredo, Luiz Felipe

AU - Terra, Rodrigo

AU - Carneiro, Lara S.F.

AU - Rodrigues, Vinícius Dias

AU - Nascimento, Osvaldo J.M.

AU - Deslandes, Andrea Camaz

AU - Laks, Jerson

PY - 2018/1

Y1 - 2018/1

N2 - Background: Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. Purpose: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons. Methods: Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect. Results: Seventysix studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05). Conclusion: Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.

AB - Background: Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. Purpose: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons. Methods: Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect. Results: Seventysix studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05). Conclusion: Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.

KW - Aging

KW - Gerontology

KW - Physical activity

UR - https://www.scopus.com/pages/publications/85039058262

UR - https://www.scopus.com/pages/publications/85039058262#tab=citedBy

U2 - 10.1123/jpah.2016-0735

DO - 10.1123/jpah.2016-0735

M3 - Review article

C2 - 28771081

AN - SCOPUS:85039058262

SN - 1543-3080

VL - 15

SP - 64

EP - 71

JO - Journal of Physical Activity and Health

JF - Journal of Physical Activity and Health

IS - 1

ER -

Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this