Effect of food on porcine gut regulatory peptides in arterial and portal venous blood

K. J. Manolas, T. E. Adrian, H. M. Dunlop, Th C. Kamilaris, A. J. Bacarese-Hamilton, S. R. Bloom, R. B. Welbourn

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The concentrations of gut regulatory peptides were monitored simultaneously in the portal and arterial circulations of 8 healthy conscious swine in the fasted state and after a standard mixed meal. The sampling was achieved via chronic cannulations of these two vessels. Portal/arterial differences of insulin and glucagon were similar to those previously described, indicating the importance of hepatic extraction of these two hormones. Portal/arterial differences for the gastrointestinal regulatory peptides were relatively small, however, and the liver is unlikely to be of major importance in the metabolism of these peptides.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalHormone Research in Paediatrics
Issue number4
Publication statusPublished - 1985
Externally publishedYes


  • Arterial
  • Gut peptides
  • Portal
  • Swine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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