Effect of grape products on blood pressure: a systematic review and meta-analysis of randomized controlled trials

Omid Asbaghi, Fatemeh Naeini, Vihan Moodi, Moein Najafi, Mina Shirinbakhshmasoleh, Mahnaz Rezaei Kelishadi, Amir Hadi, Ehsan Ghaedi, Abdulmnannan Fadel

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Previous studies have suggested that grape and its products may possess blood pressure (BP)-lowering properties. Due to inconsistencies in results, we aimed to systematically examine the effect of grape products on BP by conducting a meta-analysis of randomized controlled trials (RCTs). PubMed, Scopus, Web of Science (ISI), and Cochrane Library databases were comprehensively searched until March 2020. Human clinical trials which reported the effect of grape products supplementation on systolic BP (SBP) and diastolic BP (DBP) were included. Data were pooled using a random-effects model and expressed as a weighted mean difference (WMD) with a 95% confidence interval (CI). Twenty-eight studies comprising a total of 1344 subjects were included in our meta-analysis. The overall outcome of the meta-analysis indicates that grape products consumption can significantly reduce SBP (WMD: −3.40 mmHg, 95% CI: −6.55, −0.24, p = .03, I2 = 93.4%) and DBP (WMD: −1.69 mmHg, 95% CI: −3.12, −0.27, p = .01, I2 = 80.4%). This meta-analysis found a moderate and statistically significant reduction for either SBP or DBP with grape products compared with controls. Additional high-quality studies are needed to further evaluate the causal conclusions.

Original languageEnglish
Pages (from-to)627-645
Number of pages19
JournalInternational Journal of Food Properties
Volume24
Issue number1
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Blood pressure
  • Grape products
  • Hypertension
  • Meta-analysi
  • Systematic review

ASJC Scopus subject areas

  • Food Science

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