Effect of gut regulatory peptides on intestinal luminal fluid in the rat

P. Mitchenere; T. E. Adrian; R. M. Kirk; S. R. Bloom

doi:10.1016/0024-3205(81)90257-5

Effect of gut regulatory peptides on intestinal luminal fluid in the rat

P. Mitchenere, T. E. Adrian, R. M. Kirk, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The effect of intravenous gastrointestinal peptide hormone administration on net fluid transport in the small intestine was assessed in the rat. An increased fluid content was observed during vasoactive intestinal peptide, gastric] inhibitory peptide, and neurotensin infusions, and a decreased content with somatostatin, substance P and pancreatic polypeptide, by comparison with the control series. Motilin had no significant effect on luminal fluid volume. These results suggest that several of the gastrointestinal regulatory peptides may have an influence on the processes of fluid absorption and secretion by the small intestine.

Original language	English
Pages (from-to)	1563-1570
Number of pages	8
Journal	Life Sciences
Volume	29
Issue number	15
DOIs	https://doi.org/10.1016/0024-3205(81)90257-5
Publication status	Published - Oct 12 1981
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(81)90257-5

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title = "Effect of gut regulatory peptides on intestinal luminal fluid in the rat",

abstract = "The effect of intravenous gastrointestinal peptide hormone administration on net fluid transport in the small intestine was assessed in the rat. An increased fluid content was observed during vasoactive intestinal peptide, gastric] inhibitory peptide, and neurotensin infusions, and a decreased content with somatostatin, substance P and pancreatic polypeptide, by comparison with the control series. Motilin had no significant effect on luminal fluid volume. These results suggest that several of the gastrointestinal regulatory peptides may have an influence on the processes of fluid absorption and secretion by the small intestine.",

author = "P. Mitchenere and Adrian, {T. E.} and Kirk, {R. M.} and Bloom, {S. R.}",

note = "Funding Information: P. Mitchenere was in receipt of a grant from the Stanley Thomas Johnson Foundation, and Peter Samuel Royal Free Trust.",

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T1 - Effect of gut regulatory peptides on intestinal luminal fluid in the rat

AU - Mitchenere, P.

AU - Adrian, T. E.

AU - Kirk, R. M.

AU - Bloom, S. R.

N1 - Funding Information: P. Mitchenere was in receipt of a grant from the Stanley Thomas Johnson Foundation, and Peter Samuel Royal Free Trust.

PY - 1981/10/12

Y1 - 1981/10/12

N2 - The effect of intravenous gastrointestinal peptide hormone administration on net fluid transport in the small intestine was assessed in the rat. An increased fluid content was observed during vasoactive intestinal peptide, gastric] inhibitory peptide, and neurotensin infusions, and a decreased content with somatostatin, substance P and pancreatic polypeptide, by comparison with the control series. Motilin had no significant effect on luminal fluid volume. These results suggest that several of the gastrointestinal regulatory peptides may have an influence on the processes of fluid absorption and secretion by the small intestine.

AB - The effect of intravenous gastrointestinal peptide hormone administration on net fluid transport in the small intestine was assessed in the rat. An increased fluid content was observed during vasoactive intestinal peptide, gastric] inhibitory peptide, and neurotensin infusions, and a decreased content with somatostatin, substance P and pancreatic polypeptide, by comparison with the control series. Motilin had no significant effect on luminal fluid volume. These results suggest that several of the gastrointestinal regulatory peptides may have an influence on the processes of fluid absorption and secretion by the small intestine.

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SN - 0024-3205

VL - 29

SP - 1563

EP - 1570

JO - Life Sciences

JF - Life Sciences

IS - 15

ER -

Effect of gut regulatory peptides on intestinal luminal fluid in the rat

Abstract

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